Expiration date: 04/2027

The composition and form of issue: 

Capsules. 1 capsuse contains:

choline alphosceratus 400 mg

excipients: purified water glycerin 

the composition of the shell capsules: gelatin ethical sorbitans metilparagidroksibenzoat sodium parahydroxybenzoate sodium titanium dioxide (E171) iron (III) Metagalaxy (E172) 

in a contour acheikova packing 14 PCs. in cardboard pack 1 pack.

Solution for intravenous and intramuscular injection of 4 ml

choline alphosceratus 1000 mg

inactive ingredient: water for injections 

in ampoules of 4 ml in a contour acheikova package 1 or 3 vials, the paper cartons 1 contour packaging.

Pharmacokinetics:

Absorption and ingestion — 88% easily penetrates through the BBB, accumulates mainly in the brain (concentration in the brain reaches 45% of the level in the blood), lungs and liver of 85% of the excreted light in the form of carbon dioxide, the remainder (15%) is excreted by the kidneys and through the intestines.

Does not affect the reproductive cycle, does not have teratogenic and mutagenic effects.

Description pharmacological action:

Improves the transmission of nerve impulses in cholinergic neurons affects the plasticity of neuronal membranes and receptor function. Improves cerebral blood flow, stimulates metabolic processes in the brain, and activates the structures of the reticular formation of the brain and restores consciousness in traumatic brain damage.

Preventive and corrective effects on these pathogenetic factors involutional psychoorganic syndrome, as the change in the phospholipid composition of the membranes of neurons and reduction in cholinergic activity.

Experimental studies have shown that Gliatilin stimulates dose-dependent release of acetylcholine in physiological conditions of neurotransmission.

When ingested, is cleaved by the action of enzymes in the choline and glycerophosphate.

Gliatilin, on the one hand, as a donor of choline increases the synthesis of acetylcholine and a positive effect on neurotransmission, on the other — glycerophosphate involved in the synthesis of phosphatidylcholine (membrane phospholipid), both having a positive impact on membrane elasticity and function of receptors, which enhances synaptic transmission.

Thus, pharmacodynamic studies have shown that the effect on synaptic Gliatilin, including cholinergic neurotransmission neural plasticity membrane receptor function.

Indications:

• acute phase of TBI with mainly stem the level of the lesion (impairment of consciousness, coma, focal poluchena symptoms, symptoms of lesions of the brain stem)
  
• ischemic (acute and recovery period) and hemorrhagic stroke (recovery period)
  
• degenerative and involutional psycho-organic syndromes and consequences of cerebrovascular insufficiency, such as primary and secondary disorders of mental function characterized by memory impairment, confusion, disorientation, decreased motivation, initiative, ability to concentrate
  
• changes in emotional and behavioral sphere, emotional lability, increased irritability, loss of interest, senile psevdomelanjolia
  
• multi-infarct dementia.
  

Contraindications:

Hypersensitivity to the drug.

Application of pregnancy and breast-feeding:

Contraindicated in pregnancy and lactation.

Side effects:

Nausea (as a result dopaminergic activation), in this case, you should reduce the dose of the drug. Allergic reactions are possible.

Usually the drug is well tolerated even with prolonged use.

Method of application and dose:

Injection: in/m or/in (drip).

Capsule: inside, before eating.

Adults in acute conditions: in/m in a dose of 1000 mg/day (1 amp.) or/in — 1000-3000 mg/day. At/in the introduction, the contents of 1 amp. (4 ml) diluted in 50 ml saline solution, infusion rate — 60-80 drops per minute. Duration of treatment is usually 10 days, but if necessary, treatment can continue until the appearance of the positive dynamics and opportunities to move to the ingestion of capsules.

In chronic cerebrovascular insufficiency, changes in emotional and behavioral sphere and multi-infarct dementia: the inside — 400 mg (1 caps.) 3 times a day.

The duration of therapy is 3-6 months.

Overdose:

Symptoms: nausea.

The appearance of this symptom, it is recommended to reduce the dose of the drug.

Review:

Gliatilin-capsules — packaging Farmakor Prodakshn (Russia).

Gliatilin, ampoule packing Farmakor Prodakshn (Russia).