• Ondansetron 2mg/ml 4ml 5 vials

Expiration date: 08/2022

The composition and form of issue

Ondansetron solution for in/in and/m introduction:

1 ampoule contains ondansetron (in the form of hydrochloride dihydrate) 2, 4 and 8 mg, 10 pieces in pack.

Pharmacological action

Antiemetic. Ondansetron effectively prevents and eliminates nausea and vomiting, occurring on the background of anticancer chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron selectively block serotonin 5-HT3-receptors. I believe that in the occurrence of nausea and vomiting in anticancer therapy important role played by the stimulation of afferent fibers of the vagus nerve by serotonin released from enterochromaffin cells of gastrointestinal mucosa. Blocking 5-HT3 receptors, ondansetron prevents gag reflex. In addition, ondansetron oppresses the Central links of the gag reflex by blocking 5-HT3 receptors bottom of the IV ventricle (area postrema).

Testimony

Prevention of nausea and vomiting in the conduct of anticancer chemotherapy or radiation therapy, prevention and treatment of nausea and vomiting in the postoperative period.

Method of application and doses

Individually, depending on indications and treatment regimens.

Side effects

CNS: headache, rarely - transient visual disturbances and dizziness (with the rapid on/in the introduction), involuntary movements.

Of the cardiovascular system: rarely-pain in the chest, arrhythmia, bradycardia, hypotension.

From the digestive system: constipation, diarrhea, abdominal pain, transient increase in transaminaz in the serum.

Allergic reactions: rare - bronchospasm, angioneurotic edema, urticaria, in isolated cases, anaphylactic reactions.

Other: feeling of warmth and rush of blood to the head and epigastric region.

Contraindications

The first trimester of pregnancy, hypersensitivity to ondansetron.

Application of pregnancy and breastfeeding

Ondansetron is contraindicated in the first trimester of pregnancy. If necessary, use during lactation should stop breastfeeding.

Special instructions

When used in patients with mild and severe disorders of liver function is not recommended to exceed the dose 8 mg/day.

With careful use of Ondansetron in surgical interventions on the abdominal cavity, as its use may mask progressive ileus.

Storage conditions and shelf life

In protected from light place, at temperature not exceeding 25 °C. shelf Life — 2 years.

Ondansetron
2mg/ml
4ml
5
vials

  • $11.10