Expiration date: 03/2025

Release form

Concentrate for preparation of infusion solution

Composition

1 ml of concentrate contains cyclosporine 50 mg

Packaging

10 ampoules of 1 ml.

Pharmacological action

Immunosuppressive. Sandimmune block the cell cycle of resting lymphocytes in the G0 or G1 phase and inhibits antigen-triggered the production and secretion of lymphokines (including interleukin?2, a growth factor for T-lymphocytes) activated T-lymphocytes.

Testimony

Transplantation of solid organs (kidney, liver, heart, heart-lung complex, lung, pancreas) and bone marrow, endogenous uveitis, nephrotic syndrome, distinct forms of rheumatoid arthritis in active phase, severe psoriasis and atopic dermatitis.

Contraindications

Hypersensitivity.

Application of pregnancy and breastfeeding

During pregnancy Sandimmune should be used with caution. Breastfeeding at the time of treatment must be discontinued.

Method of application and doses

The selection of the initial dose and the correction mode Sandimmune in the process of treating a given clinical and laboratory parameters and values of drug concentration in plasma, determined daily.

Side effects

Abdominal pain, anorexia, nausea, vomiting, diarrhea, headache, weakness, paresthesia, cramps, muscle spasms, myopathy, tremor, hypertension, impaired renal function and liver, edema, pancreatitis, reversible dysmenorrhea and amenorrhea, anemia, thrombocytopenia, in some cases accompanied by microangiopathic hemolytic anemia and renal insufficiency, hyperkalemia, hyperuricemia, hypomagnesemia, weight gain, gingival hypertrophy, hypertrichosis, increased susceptibility to infections, development of malignancy and lymphoproliferative disorders.

Storage conditions

The drug should be stored out of reach of children, at temperature not above 20°C.