Expiration date: 05/2025

The composition and form of issue:

Solution for subcutaneous injection 1 amp. contains:

Tactivin 0.1 g

sodium chloride of 8.85 g

excipients: water for injection up to 1 l 

in 1 ml ampoules, complete with a knife ampulnam, in a cardboard bundle 5 or 10 ampoules.

Description pharmaceutical form:

Colorless transparent odorless liquid.

Feature:

The preparation of polypeptide nature in the form of solution for injection.

Description pharmacological action:

Is immunostimulating agent. With immunodeficiency the drug normalizes the quantitative and functional indices of immunity, stimulates the production of lymphokines, including &alpha - and &gamma - interferon restores the activity of T-killer cells, functional activity of hematopoietic stem cells and normalizes a number of other indicators of the intensity of immunity. Activates the macrophage system.

Indications:

Immunodeficiency States in adults and children (from 6 months to 14 years), resulting in such diseases as:

• infectious purulent and septic processes
  
• lymphoproliferative diseases (Hodgkin's disease, lymphocytic leukemia)
  
• malignant neoplasms
  
• persistent dysfunction of the thymus (radiation sickness, tumors of the thymus, surgical removal of the thymus)
  
• multiple sclerosis
  
• tuberculosis
  
• recurrent eye herpes
  
• psoriasis
  
• shingles
  
• dermatitis and dermatosis
  
• frequently recurring viral respiratory infection
  
• urological diseases of infectious etiology
  
• lung disease
  
• chronic viral hepatitis
  
• surgery (in the preoperative and postoperative periods)
  
• thymomegaly.
  

Contraindications:

• pregnancy
  
• the period of breastfeeding.
  

Side effects:

Allergic reactions.

Method of application and dose:

N/a, adult — 1 ml 0,01% solution (equivalent to 40 mg/m2 or 1-2 mg/kg) was administered the night, 1 time a day, daily for 5-14 days. If necessary, treatment is continued for 1 month 2 ml every 3rd day.

When persistent disorders of immunity Tactivin administered for 5-14 days at 2 ml daily and then 2 times a week for 2 ml within 6 months. Repeated courses of treatment prescribed for the indicators of immune status.

In multiple sclerosis the drug is administered daily 1 ml for 5 days, then — 2 ml 2 times a week for life.

In severe cases of multiple sclerosis Tactivin administered in complex therapy with corticosteroids (in the stage of application of corticosteroids 1 time per day). The reference drug is administered in the morning and Tactivin in the evening on 1 ml, in compliance with the interval between administration of corticosteroids and Tactivin 10-12 hours.

For the treatment of surgical patients Tactivin administered before surgery and 1 ml for 2 days and after it — within 5-14 days.

Malignancy Tactivin administered 5-6 day courses, 1 ml in between the courses of basic therapy.

For the treatment of recurrent ophthalmic herpes administered 0.1 ml of the drug under the conjunctiva, which is 4 mg/m2 or 0.1–0.2 ág/kg/day with an interval of 1 day for 4-5 days, either 1 ml s/C for 7-10 days.

If shingles inject 1 ml of Tactivin daily for 7-10 days.

The treatment can be repeated after 2-3 weeks.

In hepatitis of various etiologies Tactivin administered at 2-3 ml daily for 10-12 days in combination with basic drugs. The course of immune repeated after 7 days.

Children from 6 months to 14 years the drug is prescribed n/a the rate of 2-3 mg per 1 kg of body weight.

Frequent acute respiratory diseases, acute respiratory infections, septic infections, atopic dermatitis, complicated by the herpes virus, Tactivin administered daily for 7-10 days in combination with basic drugs. The subsequent introduction of the drug — 1 injection every other day for 1-2 weeks.

In malignant tumors and hepatitis in children treatment regimen does not differ from treatment regimens in adults.

It is recommended to enter in the evening between 17 and 20 hours.