Expiration date: 08/2025
The composition and form of issue:
1 ml solution for injection contains zianokobalamina (vitamin B12) 200 or 500 mcg in 1 ml ampoules, in a cardboard box 10 PCs
Pharmacological action:
Involved in the transfer of methyl fragments, the formation of choline, methionine, creatine, nucleic acids, maturation of erythrocytes, contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups.
Indications:
Anaemia (Addison-Barmera, nutritional, macrocytic, iron deficiency, post-hemorrhagic, aplastic caused by the toxic substances and medicines), cirrhosis, hepatitis, myelosis polyneuritis, radiculitis, trigeminal neuralgia, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, a disease syndrome, skin diseases, injuries of the peripheral nerves.
Contraindications:
Thromboembolism, angina.
Side effects:
Agitation, pain in the heart region, tachycardia, allergic reactions.
Drug interactions:
Inconsistent (in one sprite) with a thiamine bromide, Riboflavin.
Method of application and dose:
P/to, in/m, in/in and intralumbalno.
When anemia Addison-Barmera — 100-200 mcg a day for anemia of Addison-Barmera with symptoms of funicular myelosis and macrocytic anemias with disorders of the nervous system — 500 µ g or more on injection (in the first week daily, then at intervals between wvedeniami to 5-7 days). At the same time, appoint folic acid. During remission in the absence of phenomena funicular myelosis introduced for maintenance therapy of 100 mcg 2 times a month, and in the presence of neurological phenomena — at 200-400 mcg 2-4 times a month.
When post-hemorrhagic iron deficiency and anemia on 30-100 mcg 2-3 times a week in aplastic anemia (especially in children) — 100 micrograms before the onset of clinical hematological improvement in nutritional anemia in children at an early age and preterm — 30 mcg/day for 15 days.
In diseases of the Central nervous system and neurological diseases with pain syndrome is administered in increasing doses from 200 to 500 micrograms per injection, and the improvement in the 100 mg/day rate — up to 2 weeks.
In traumatic lesions of peripheral nerves — at 200-400 mcg every other day for 40-45 days.
In hepatitis and cirrhosis — 30-60 mcg per day or 100 micrograms a day for 25-40 days.
Dystrophy in children of early age, down syndrome and cerebral palsy — by 15-30 mcg every other day.
When funicular myelosis, amyotrophic lateral sclerosis, multiple sclerosis administered sometimes spinal canal to 15-30 g (gradually increasing the dose to 200-250 mg).
Precautions:
When stenocardia should be used with caution and in smaller doses.
