Expiration date: 10/2025
Structure and Composition:
Eye drops 0.25 ml of 1%
timolol maleate 3.42 mg
(Corresponds to 2.5 mg of timolol)
Excipients: Benzalkonium chloride - 0.03 mg (as a preservative), disodium edetate dihydrate povidone monosodium phosphate dihydrate Sodium monohydrogen phosphate dodecahydrate water for injection
in vials-droppers of 5 ml in box of 1 vial.
0.5% eye drops 1 ml
timolol maleate 6.83 mg
(Corresponding to 5 mg timolol)
Excipients: Benzalkonium chloride - 0.03 mg (as a preservative), disodium edetate dihydrate povidone monosodium phosphate dihydrate Sodium monohydrogen phosphate dodecahydrate water for injection
in vials-droppers of 5 ml in box of 1 vial.
Pharmachologic effect:
Beta-adrenoceptor blocking and reduces the secretion of aqueous humor, reducing the intraocular pressure.
Pharmacokinetics:
Well absorbed by the retina and the nasal mucosa, it is excreted in the urine.
Clinical Pharmacology:
In topical application the intraocular pressure decreases after 20 minutes, the maximum effect - in 2-3 hours duration - 24 hours.
Indications:
Glaucoma (all forms).
Contraindications:
Hypersensitivity, severe obstructive airways disease, sinus bradycardia, AV block, heart failure, severe allergic rhinitis.
Application of pregnancy and breastfeeding:
When used in the I trimester of pregnancy must be weighed the possible benefits and potential risk.
Side effect:
Nausea, diarrhea, weakness and fatigue, disorientation, hallucinations, respiratory failure, bradyarrhythmia, hypotension, bronchospasm, reduction of tear secretion, blepharitis, conjunctivitis, keratitis, allergic reactions, tachyphylaxis.
Drug Interactions:
Compatible with miotocs and carbonic anhydrase inhibitors.
Dosage and administration:
At the beginning of therapy instilled 1 drop preparation Arutimol 0.25 or 0.5% in the diseased eye two times a day.
If the intraocular pressure is normal with regular use, the dosage should be limited to 1 times daily 1 drop of the drug.
Arutimolom treatment is carried out, as a rule, for a long time. Suspension or dosage change be made only by order of the physician.
Shelf life:
After opening the vial 6 weeks.
