Expiration date: 05/2027

Composition

Per 1 ml:

Active ingredients: motherwort herb tincture - 720.00 mg, ethyl bromoisovalerianate - 20.00 mg, peppermint leaf oil (peppermint oil) -1.42 mg.

Excipients: purified water - up to 1 ml.

To obtain 100 ml of motherwort tincture, 20 g of motherwort herbs and a sufficient amount of ethyl alcohol 70% are used.

The dosage form

of the drop for oral administration

Description

Transparent liquid of greenish-brown color, with a characteristic odor. The presence of a suspension of small particles is allowed. Sediment formation is allowed during storage.

Pharmacodynamics

A combined drug, the effect of which is determined by the properties of its constituent substances. It has a sedative and antispasmodic effect, moderate cardiotonic effect (slows down the rhythm and increases the strength of heart contractions), has moderate hypotensive properties.

Ethylbromisovalerianate has sedative and antispasmodic effects due to irritation, mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central nervous system and increased inhibition in cortical neurons and subcortical structures of the brain, as well as a decrease in the activity of central vasomotor centers and a direct local antispasmodic effect on smooth muscles.

Motherwort herb has a pronounced sedative (soothing), moderate cardiotonic (slows down the rhythm and increases the strength of heart contractions) effect, moderate hypotensive effect.

Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the cold receptors of the oral mucosa and reflexively dilate mainly the vessels of the heart and brain. Eliminates the phenomena of flatulence by irritating the receptors of the mucous membrane of the gastrointestinal tract (GIT), increasing intestinal motility.

Pharmacokinetics

There are no data on the pharmacokinetics of ethylbromisovalerianate, motherwort and peppermint components.

Indications for use

Sleep disorders, neurosis-like conditions accompanied by increased irritability and excitability, states of arousal with pronounced vegetative manifestations, as an antispasmodic agent for intestinal spasms, as well as as a symptomatic (soothing and vasodilating) agent for functional disorders of the cardiovascular system.

Contraindications

• Hypersensitivity to the components of the drug,
• severe renal and/or liver dysfunction,
• erosive and ulcerative lesions of the gastrointestinal tract (acute phase),
• pregnancy,
• the breastfeeding period,
• children under 18 years of age (efficacy and safety have not been established).

Use during pregnancy and lactation

The safety of Corvalol Phyto during pregnancy has not been established and its use during this period is contraindicated.

There is no data on the penetration of the components of the drug into breast milk, therefore, if necessary, use during lactation, the issue of stopping breastfeeding should be resolved.

Side effects

From the immune system: allergic reactions,

From the central nervous system: drowsiness, weakness, dizziness, decreased ability to concentrate,

From the cardiovascular system: slowing of the heart rate,

From the gastrointestinal tract: dyspepsia.

These phenomena disappear with a decrease in the dose of the drug or discontinuation of the drug.

With prolonged use of high doses of the drug, drug dependence may develop, as well as the accumulation of bromine in the body and the development of symptoms of bromism, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.

If any of the side effects listed in the instructions worsen, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

When Corvalol Phyto is used simultaneously with drugs that inhibit the activity of the central nervous system (sedatives, hypnotics, antipsychotics, tranquilizers), mutual effects may be enhanced.

Enhances the effect of antispasmodic, analgesic agents.

Alcohol enhances the effect of the drug and its toxicity.

Method of administration and dosage

For adults

Take orally, before meals, 3 times a day for 30 drops, pre-dissolved in a small amount (30-40 ml) of water.

The course of treatment is 4 weeks (28 days).

The duration of the appointment can be extended on the recommendation of a doctor.

Overdose

Overdose is possible with frequent and prolonged use of the drug. If the recommended doses are exceeded, dose-dependent side effects may increase.

Symptoms: weakness, drowsiness, dizziness. With prolonged use, chronic bromine intoxication may occur (See section Side effects).

Treatment: symptomatic.

Special instructions

There is no experience of using the drug in children under 18 years of age, during pregnancy and during breastfeeding.

Prolonged use of the drug in high doses is not recommended, due to the possible toxic effect of bromine accumulation in the body.

Alcohol should not be consumed during the use of the drug.

Corvalol Phyto contains 47.5% ethyl alcohol, so when taken orally in the maximum single dose of the drug, the content of absolute ethyl alcohol (ethanol) is 0.308 g, in the maximum daily dose - 0.923 g.

Influence on the ability to drive motor vehicles and manage mechanisms

Due to the possibility of dizziness, decreased concentration of attention and other side effects associated with taking the drug, during treatment, patients are advised to refrain from driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor and motor reactions.

Form of release

Drops for oral administration.

Packaging

25 or 50 ml in vials (dropper bottles) made of glass, sealed with dropper stoppers, with screw-on lids.

The vial (dropper bottle), together with the instructions for use, is placed in a pack of cardboard.

Conditions of release from pharmacies

Without a prescription

Storage conditions

Store at a temperature not exceeding 25 C.

Keep out of reach of children.

Expiration date

2 years. Do not use after the expiration date indicated on the package.