Expiration date: 10/2026
Composition
Active ingredient: nitrofural - 4 mg. Auxiliary substances: macrogol-400 (polyethylene glycol-400) - 904 mg, povidone K-30 - 20 mg, purified water - up to 1 ml.
Dosage form
A viscous liquid from yellow to brownish-yellow in color.
Pharmacodynamics
Antimicrobial agent, a derivative of nitrofuran. Bacterial flavoproteins, restoring the 5-nitro group, form highly reactive amino derivatives capable of causing conformational changes in proteins (including ribosomal) and other macromolecules, leading to bacterial death. It is active against Gram-positive and Gram-negative bacteria (including Staphylococcus spp., Streptococcus spp., Escherichia coli, Clostridium perfringens). Resistance develops slowly and does not reach a high degree.
Pharmacokinetics
With topical and external application, there is little absorption. Penetrates through histohematic barriers and is evenly distributed in fluids and tissues. The main pathway of metabolism is the restoration of the nitro group. It is excreted by the kidneys and partially with bile.
Indications for use
Externally: purulent wounds, pressure sores, grade II-III burn, minor skin lesions (including abrasions, scratches, cracks, cuts). Locally: blepharitis, conjunctivitis, osteomyelitis, empyema of the paranasal sinuses and pleura, urinary tract infections - flushing of cavities, acute tonsillitis, stomatitis, gingivitis. If necessary, please consult your doctor before using the medicine.
Contraindications
Hypersensitivity to nitrofural, nitrofuran derivatives and / or other components of the drug, bleeding, allergodermatosis, severe renal impairment. Use during pregnancy and lactation Before using the drug, if you are pregnant, or assume that you could be pregnant, or are planning to become pregnant, consult your doctor during breastfeeding. Use during pregnancy and lactation is possible if the intended benefit to the mother outweighs the potential risk to the fetus and child.
Use in children
Keep away from children
Side effects
Adverse reactions are grouped according to the lesion of organs and organ systems according to the MedDRA dictionary. Disorders of the immune system: allergic reactions. Skin and subcutaneous tissue disorders: itchy skin, dermatitis. If any of the side effects listed in the instructions worsen, or any other side effects are noted that are not listed in the instructions, you should immediately inform your doctor.
Interaction
Incompatible with epinephrine (adrenaline), procaine (novocaine), tetracaine, resorcinol (resorcinol) and other reducing agents, as it decomposes to form products colored pink or brownish. Incompatible with potassium permanganate, hydrogen peroxide and other oxidizing agents due to the oxidation of the drug.
Method of administration and dosage
Locally, externally. An aqueous 0.02% solution of nitrofural is prepared immediately before use: 5 ml of concentrate is dissolved in 100 ml of boiled or distilled water. Externally. In the form of an aqueous 0.02% solution, wounds, pressure sores, II-III degree burns, minor skin injuries (including abrasions, scratches, cracks, cuts) are irrigated and wet bandages are applied. Locally. Blepharitis, conjunctivitis - instillation of an aqueous 0.02% solution into the conjunctival sac. Osteomyelitis after surgery is the washing of the cavity, followed by the application of a wet bandage. Empyema of the paranasal sinuses (including sinusitis) - flushing of the cavity, empyema of the pleura - after removal of pus, the pleural cavity is washed and 20-100 ml of an aqueous 0.02% solution is injected. An aqueous 0.02% solution with an exposure of 20 minutes is used to flush the urethra and bladder. For acute tonsillitis, stomatitis, gingivitis, mouth and throat rinsing with a warm solution of 100 ml of an aqueous 0.02% solution 2-3 times a day. The duration of treatment according to the indications depends on the nature and location of the affected area. If there is no improvement after treatment, or the symptoms worsen, or new symptoms appear, it is necessary to consult a doctor. Use the drug only according to the indications and the method of use indicated in the instructions for use.
Special instructions
Use of the drug in patients with severe burns on large surfaces: with impaired renal function, progression of renal failure (uremia, impaired water and electrolyte balance, metabolic acidosis) is possible. If the symptoms of the disease do not decrease or worsen, it is necessary to consult a doctor. The effect of the drug on the ability to drive vehicles and mechanisms The drug does not affect the ability to drive vehicles or engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Storage conditions
Within the specified shelf life, the opened bottle should be stored for 3 weeks at a temperature not exceeding 25 ° C. Do not freeze. The diluted solution should be stored for 2 days at a temperature not exceeding 25 ° C.
Expiration date
2 years old
