Expiration date: 06/2025
Composition and form of issue:
Ointment for external use 2% 1 g contains:
sodium fusidate 20 mg
auxiliary substances: lanolin, cetyl alcohol liquid paraffin white soft paraffin
in the box to 15 grams in a cardboard bundle 1 tuba.
Cream for external use 2% 1 g contains:
fusidic acid anhydrous 20 mg
excipients: butylhydroxyanisole cetyl alcohol, glycerol 85% liquid paraffin, potassium sorbate Polysorbate 60 white soft paraffin purified water
in the box to 15 grams in a cardboard bundle 1 tuba.
Pharmacokinetics:
The permeability of fusidic acid through the intact skin is low, is 0, 54% of the applied amount of the drug.
Description of the pharmacological action:
Sodium fusidate refers to a group of fuzidinu — antimicrobial compounds, mechanism of action which involves a violation of protein synthesis in the bacterial cell. Blocking factor g elongation, they prevent its binding to ribosomes and guanosine triphosphate, which interrupts the release of energy necessary for protein synthesis, and leads to the death of the bacterial cell. There are no reports of cross-resistance to sodium fusidate.
Sodium fusidate sensitive Staphylococcus aureus, Corynebacterium minutissimum, Streptococcus pyogenes, gram-negative microorganisms, Pseudomonas spp.
Indications:
Bacterial skin infections in adults, adolescents, children and newborns.
Contraindications:
Hypersensitivity to any component of the drug.
Application for pregnancy and breastfeeding:
It should be used with caution during pregnancy and breastfeeding, although experimental data do not confirm the embryotoxic or teratogenic effect of the drug.
Side effect:
The frequency of side effects is classified as very rare and is approximately 2:1,000,000 courses of treatment.
Skin and subcutaneous tissue (listed in descending order of frequency): itching, irritation, burning sensation and tingling, dry skin, rash (erythematous, maculopapular, pustular), contact dermatitis, eczema, erythema, urticaria, angioedema, periorbital edema.
Immune system: allergic reactions.
Method of application and doses:
Locally, externally.
In adults and children ointment or cream applied to the affected area of skin 3 times a day for 10 days.
Special instruction:
When applying ointment Futsidin the person must be careful, because if it enters the eye sodium fusidate causes irritation of the conjunctiva.