Expiration date: 11/2026
Clinico-pharmacological group
(Antiviral and immunomodulatory drug)
Pharmacological action
Air Molok of sturgeon (standardized and purified mixture of nucleic acids), has immunostimulatory and antiviral effect. Activates antiviral, antifungal and antimicrobial immunity. Exhibits antiviral activity against RNA and DNA viruses.
Course application in complex therapy of AIDS/HIV infection increases the level of CD4-lymphocytes in the blood, continuing for 1-1.5 months after completion of treatment. At the same time reduced the viral load in the body.
In recurrent HSV infection reduced length of relapse and long-term remission occurs.
Use in patients With chronic hepatitis C contributes to the reduction of the replicative activity of hepatitis C virus and translates the process into a latent phase.
Pharmacokinetics
When the/m introduction the recommended dose absorption quick. Tmax - 0.5 h T1/2 is 36 h. after 24 h begins to decrease the drug concentration in the blood associated with its distribution in organs and tissues. When repeated administration of the drug every 24 h for 5 days, there is a process of its accumulation in the blood and bone marrow. After the fifth injection, the concentration of the drug in all organs and tissues is reduced.
Is inferred (unchanged and as metabolites) excreted by the kidney (60%) and partly in the faeces (15%).
Dosage
V/m (slowly over 1-2 min) adults with HIV or AIDS 5 ml of 1.5% solution for injection (75 mg in terms of dry substance) 2 times/day, for 14 days. If necessary 1-1.5 months may be assigned a second course of therapy.
Herpes - 5 ml 1.5% solution (75 mg) intramuscularly 2 times/day for 10 days.
The hepatitis C 5 ml 1.5% solution (75 mg) 2 times/day, for 14 days. In the next 14 days the drug is administered in the same daily dose through the day.
Drug interactions
Moderately increases the effect of anticoagulants.
Pregnancy and lactation
Contraindicated during pregnancy and lactation.
Side effects
Rarely, intermittent fever (up to 38°C), hyperemia and soreness at the injection site.
Testimony
In combination therapy:
— HIV infection, AIDS,
— hepatitis C and recurrent herpes infection in HIV-infected patients.
Contraindications
— hypersensitivity
— pregnancy,
— lactation,
— the children's age.
Special instructions
In order to reduce pain to enter I/m slowly over 1-2 min.
The solution for injection should be fully used immediately after opening the vial, do not store opened vials.
In/in the introduction of the drug is not allowed!
