Expiration date: 11/2025 

AMPROLIUM 30% 

The name (lat.): Pulvis Amprolium 30 % solubilis 

The composition and form of issue

Water-soluble powder. Anticoccidial preparation, 100 g of which contains 30 g of amprolium hydrochloride and lactose as filler. Is a powder from white to light yellow color, soluble in water. Pre-Packed in packages of 1 kg.

Pharmacological properties

Amprolium hydrochloride has a wide range anticoccidial action, effective against Eimeria tenella, E. acervulina, E. necatrix, E. maxima, E. mivati, E. brunetty and other species of coccidia parasitizing in birds. Anticoccidial action of amprolium due to the proximity of its chemical structure to thiamine (vitamin B1) required for the life of coccidia. Due to the active transport amprolium better than thiamine, penetrates into the cell of the parasite and occupies the active binding of the vitamin, which leads to disruption of carbohydrate metabolism and death of the parasite. The structure of the cell membrane of the intestinal mucosa of birds and mammals almost not permeable to amprolium, making the preparation virtually non-toxic when used in therapeutic doses. The main part of amprolium (up to 97%) excreted in faeces. The drug prevents the formation of protivokariesnoe immunity, is compatible with the known vitamins and feed additives used in poultry. Refers to low-hazard substances (4 hazard class according to GOST 12.1.007). The LD50 when administered orally to white mice is 135,000 mg/kg. 

At the recommended dose does not cause complications in birds.

Testimony

Coccidiosis in broiler chickens, repair young and breeding birds.

The dose and method of application

Used in a mixture with feed or water. With drinking water and amprolium are used: broilers prophylactically — with 3 to 5 days of age during the cultivation period in a daily dose of 200 g of drug in 500 l drinking water (120 mg DV per 1 liter of water), excluding from the diet 5 days before slaughter; for therapeutic purposes — within 5 — 7 days in a daily dose of 400 g product per 500 l of drinking water (240 mg DV per 1 liter of water). Repair young animals with the preventive purpose — with 3 to 5 days of age until 16 weeks of age in a daily dose of 400 g product per 500 l of drinking water (240 mg DV per 1 l of water). with curative intent within 5 — 7 days in a daily dose of 400 g product per 500 l of water (240 mg DV per 1 liter of water). During the conduct of treatment and prevention measures the solution of amprolium should be for poultry the only source of drinking water. In mixture with feed use amprolium poultry: broilers prophylactically — with 3 to 5 days of age during the period of cultivation in a dose of 400 g product per ton of feed (120 mg DV per kg of feed), excluding from the diet 5 days before slaughter; for therapeutic purposes — within 7 — 10 days at a dose of 800 g per ton of feed (240 mg DV per kg of feed). Repair young animals with the preventive purpose — with 3 to 5 day-old to 16-week age in a dose of 400 g product per ton of feed (120 mg DV per kg of feed); for therapeutic purposes — within 7 — 10 days at a dose of 800 g per ton of feed (240 mg DV per kg of feed).

Side effects

In recommended doses are observed.

Contraindications

Do not use amprolium for chickens after 16 weeks of age. Do not use amprolium in chickens, laying hens, because the drug excreted in the eggs. Do not use amprolium in conjunction with other koktsidiostatiki.

Special instructions

Slaughter of poultry for meat is allowed in 5 days after you stop using the drug. Poultry forcedly killed before expiration of the term, used to feed carnivorous animals or for the production of meat and bone meal. All work with the drug should be with the use of special clothing and personal protective equipment (rubber gloves, goggles, respirator). During operation it is prohibited to smoke, drink and eat. After work, wash with soap hands and face, rinse mouth thoroughly with water. Containers under the drug must not be used for domestic purposes.

Storage conditions

List B. In dry protected from light place at temperature not exceeding 30 °C. shelf Life — 5 years. A mixture of product with feed is stable for 7 days.