Expiration date: 04/2025
Group affiliation:
A proteolytic agent for topical application
Description of the active substance (INN):
Chymotrypsin
Dosage form:
lyophilisate for preparation of solution for local and external use
Pharmacological action:
Proteolytic means protein nature. Prepared from the pancreas of cattle. When the/m introduction anti-inflammatory effect, the local application splits nekrotizirovannye tissue and fibrinous education dilute viscous secretion, exudates, blood clots. Hydrolyzes proteins and Peptones with the formation of low molecular weight peptides, cleaves the residues formed when aromatic amino acids (tyrosine, triptophan, phenylalanine, methionine).
Indications:
Thrombophlebitis, periodontal disease (inflammatory-dystrophic form), osteomyelitis, sinusitis, otitis, iritis, iridocyclitis, intracapsular cataract extraction, bleeding in the anterior chamber of the eye, swelling of the periorbital region after operations and injuries, tracheitis, bronchitis, empyema, pleural effusion, burns, purulent wounds, bed sores (applied topically).
Contraindications:
Hypersensitivity, malignant neoplasms, decompensated forms of pulmonary tuberculosis, chronic heart failure II-III century., degeneration and liver cirrhosis, infectious hepatitis, pancreatitis, bleeding diathesis, pulmonary emphysema with respiratory failure. Cannot be inserted into the bleeding cavity, applied to the ulcerated surface of cancer.C caution. Empyema of tuberculous etiology (absorption of exudate can contribute to the development of bronchopleural fistula).
Side effects:
Allergic reactions, increase in body temperature to subfebrile, tachycardia. After the introduction of inhalation: mucous membrane irritation of the upper respiratory tract, hoarseness. When subconjunctival administration: irritation and swelling of the conjunctiva (in this case, it is recommended to reduce the concentration of the applied solution). When the/m introduction: pain and redness at the injection site.
Method of application and dose:
Local. On the purulent wound surface is applied for 8 h in sterile napkin moistened with a solution of 25-50 mg of chymotrypsin in 10-50 ml of 0.25% solution of procaine. In/m, adults - 2.5 mg 1 times a day, dissolved immediately before use 5 mg in 1-2 ml of sterile 0.9% NaCl solution or 0.5-2% solution of procaine. The course of treatment - 6-15 injections.
