Expiration date: 12/2025

International name: 

Trypsin+Chymotrypsin (Trypsin+Chymotrypsin)

Group affiliation:

A proteolytic agent for topical application

Description of the active substance (INN):

Trypsin+Chymotrypsin

Dosage form:

lyophilisate for preparation of solution for local and external use

Pharmacological action:

Proteolytic combined agent of a protein nature. Prepared from the pancreas of cattle. When local and external use nekrotizirovannye breaks down tissue and fibrinous education dilute viscous secretion, exudates, blood clots. Hydrolyzes proteins and Peptones with the formation of low molecular weight peptides, cleaves the residues formed when aromatic amino acids (tyrosine, triptophan, phenylalanine, methionine).

Indications:

Suppurative lung disease (bronchiectasis, lung abscess, atelectasis, pleural effusion). Diseases of the respiratory tract: purulent sinusitis, purulent otitis media (acute, subacute, chronic), stageit with viscous exudate, after tracheostomy to facilitate the removal of thick viscous exudate, chronic rhinitis. Burns, bedsores, trophic ulcers, festering wounds. In ophthalmology: diseases of the cornea (ulcer, herpetic keratitis), burn mucous membranes of the eyes, obstruction lesovyvozka ducts, sluggish healing of wounds of the eyelid skin.

Contraindications:

Hypersensitivity, malignant neoplasms, destructive forms of pulmonary tuberculosis, chronic heart failure II-III century., pulmonary emphysema with respiratory failure. Cannot be inserted into the bleeding cavity, applied to the ulcerated surface of cancer.C caution. Empyema of tuberculous etiology (absorption of exudate can contribute to the development of bronchopleural fistula).

Side effects:

Allergic reactions, increase in body temperature to subfebrile, tachycardia. After the introduction of inhalation: mucous membrane irritation of the upper respiratory tract, hoarseness. Ophthalmic: irritation and swelling of the conjunctiva (in this case, it is recommended to reduce the concentration of the applied solution).

Method of application and dose:

Locally, externally. For the treatment of purulent wounds and ulcers sterile napkin moistened with a solution: 25-50 mg in 10-50 ml of 0.25% solution of procaine, impose a period of 2 to 24 hours (depending on the thickness of the necrotic masses) on the wound surface. Bandage change every 3-5 days. In thermal burns III. the scab is a thin layer of the drug at the rate of 1 g per 100 sq cm wound surface, cover with a dressing moistened with 0.9% NaCl or 0.25% solution of procaine, impose waterproof bandage. Change dressings produce a day. During each shift bandage and remove easily detachable parts of the necrotic tissue. With the wounds covered by thick scab before applying the bandage to his cut. When suppurative bronchopulmonary disease using inhalation of 25-30 mg of the drug diluted in 5 ml of distilled water, 1-3 times a day. The solution can also be entered via a bronchoscope, endotracheal probe, a tracheostomy. The solution is to add antibiotics, bronchodilators PM. For the treatment of ulcers, burns of the cornea and keratitis are used in the form of eye baths in a solution of 1:500 daily, for 2-3 days, buried 2 cap 0.25% solution, 4 times daily for 1-2 days. Obstruction lesovyvozka ducts and the wounds of the eyelid skin: washed lesovyvozka ducts or irrigate wounds 1% solution. Solutions prepared ex tempore. For chronic rhinitis instilled or irrigated with a solution (5 mg in 5 ml 0.9% NaCl solution) of the drug in the nasal cavity 2-3 times a day. In chronic purulent otitis, complicated by cholesteatoma, after washing the cavity of 0.9% NaCl solution, buried 0.5% solution (diluted in 0.9% NaCl solution), 2-3 times a day for 20-30 minutes.

Special instructions:

In the hours after inhalation, the patient should be careful to expectorate or should be removed by suction.