Expiration date: 10/2026

Action:

Antineoplastic

Composition:

Etoposide-100mg.

Spurt. other substances: ethanol 96.7% - 260.6 mg, benzyl alcohol - 20.0 mg, macrogol 300, Polysorbate 80, citric-TA,

Pharmacological action

The drugs — antitumor.

Induces breaks of single and double strands of DNA, forms intracellular free radicals, inhibits topoisomerase II, inhibits the entry of cells into mitosis, mainly in the S and G phases.

The testimony of the drug Etoposide-Ebewe

Germinogenic tumors (testicular and chorionic carcinoma), ovarian cancer, lung cancer (small cell and non - small cell), stomach cancer, Hodgkin's disease, non-Hodgkin's lymphoma (mono-and combination therapy).

Contraindications

Hypersensitivity, severe myelosuppression, severe liver and kidney dysfunction, pregnancy, breast-feeding, alcoholism, children under 2 years of age.

Use during pregnancy and breast-feeding

Contraindicated. At the time of treatment should stop breastfeeding.

Side effect

Leukopenia, anemia, thrombocytopenia, increased uric acid, nausea, vomiting, anorexia, diarrhea, gastrointestinal infections, hypotension, drowsiness, fatigue, allergic reactions (chills, fever, bronchospasm), alopecia.

Dosage and administration

Inside, adding 250 ml of water to the concentrate, 50 mg / m2 of the body surface for 21 days, then on the 28th day, 4-6 repeated courses. In/, infusion (dilution 1: 50-1: 100 in a saline solution of sodium chloride or glucose) — 50-100 mg/m2 daily or 120-150 mg/m2 every other day for 5 days with a repeat of the course after 2-3 weeks, other schemes (with other doses and intervals), depending on the sensitivity and tolerability of the drug.

Precautionary measures

Before and during treatment requires constant monitoring of the peripheral blood picture, the General condition of the patient (including examination of the oral mucosa). It should not be used during the work of drivers of vehicles and people whose profession is associated with increased concentration.