Expiration date: 04/2025
Composition
1 ml contains dopamine hydrochloride 5 or 40 mg
Packaging
10 ampoules of 5 ml.
Pharmacological action
Dopamine cardiotonic and hypertensive agent. Dopamine receptor agonist, is their endogenous ligand.
The beginning of therapeutic effect within 5 minutes on the background I/V administration and lasts for 10 min.
Testimony
Shock different Genesis (cardiogenic, postoperative, infectious-toxic, anaphylactic, hypovolemic /only after the restoration BCC/). Acute cardiovascular insufficiency of various Genesis, syndrome of low cardiac output in cardiac surgery patients, arterial hypotension, to enhance diuresis in case of poisoning.
Contraindications
Hypertrophic obstructive cardiomyopathy, pheochromocytoma, ventricular fibrillation, hypersensitivity to dopamine.
Application of pregnancy and breastfeeding
During pregnancy and lactation (breastfeeding) Dopamine is used only in those cases when expected benefit for mother exceeds potential risk for fetus or child.
Method of application and doses
Set individually depending on the severity of the shock, the magnitude of blood pressure and the patient's response to the introduction of dopamine. With the aim of improving the myocardial contractility and increase urine output give/drip in 100-250 µg/min In case of need for exposure to the AD increase the dose to 300-500-700 µg/min.
Children Dofamin-Ferein administered at a dose of 4-6 mcg/kg/min.
The duration of dopamine may be to 28 days.
The maximum dose: when in/drip in adults - 1500 mg/min.
Side effects
From the side of cardiovascular system: tachycardia or bradycardia, chest pain, increase or decrease in blood pressure, conduction disorders, broadening of the QRS complex, vasospasm, increased end-diastolic pressure in the left ventricle, when used in high doses - ventricular or supraventricular arrhythmias.
From the digestive system: nausea, vomiting, bleeding from the gastrointestinal tract.
CNS and peripheral nervous system: more often - headache, less frequently - anxiety, restlessness, tremor of the fingers.
From the metabolic: polyuria.
Allergic reactions: in patients with bronchial asthma, bronchospasm, shock
Local reactions: when hit of dopamine under the skin - necrosis of skin, subcutaneous tissue.
Other: less often - shortness of breath, azotemia, piloerection, rarely - polyuria (with the introduction of low doses).
Special instructions
Dopamine with caution should be used if hypovolemia, myocardial infarction, cardiac arrhythmias (tachyarrhythmia, ventricular arrhythmia, atrial fibrillation), metabolic acidosis, hypercapnia, hypoxia, hypertension in the pulmonary circulation, thyrotoxicosis, closed angle glaucoma, prostatic hyperplasia, occlusive vascular diseases (including atherosclerosis, thromboembolism, thromboangiitis obliterans, occlusive disease, diabetic endarteritis, Raynaud's disease, frostbite), diabetes, bronchial asthma (if in the anamnesis there was increased sensitivity to disulfide), pregnancy, lactation, in children and adolescents under the age of 18 years.
Storage conditions
The drug should be stored out of reach of children at temperature not exceeding 25°C.
