Expiration date:  12/2021

The composition and form of issue:

Tablets, film-coated, soluble in the intestine. One tablet contains:

succinic acid 300 mg

Riboxin (inosine) 50 mg

nicotinamide 25 mg

Riboflavin mononucleotide (Riboflavin) 5 mg

Excipients: weight of PVP (povidone), calcium stearate copolymer of methacrylic acid and ethylacrylate 1,2-propylene glycol acid red 2S Tropeolin About 

in a contour acheikova packing 10 PCs., in a cardboard bundle 5 or 10 packs.

Description pharmaceutical form:

Tablets: round, biconvex, red film-coated.

Pharmacokinetics:

The drug has a high bioavailability: the presence in the composition of the tablet components mutually influence the pharmacokinetics of the components. When the absorption of succinic acid and Riboxin (inosine) disposed of quickly. Riboxin (inosine) is metabolized in the liver to form glucuronic acid and its subsequent oxidation. In small amounts excreted by the kidneys. Nicotinamide is rapidly distributed in all tissues, crosses placenta and in breast milk, metabolized in the liver with the formation of nicotinamide-N-methylnicotinamide and excreted by the kidneys. Riboflavin is unevenly distributed: the highest concentration detected in the myocardium, liver, kidneys, then the brain and other tissues. Penetrates through the placenta and into the mother's milk. Excreted by the kidneys, partly in the form of a metabolite.

Description pharmacological action:

Cytoflavin has antihypoxic effect, exerting a positive effect on the processes of energobrazovania in a cage, reduces the production of free radicals and restores the activity of antioxidant enzymes.

The drug activates cerebral blood flow, stimulates metabolic processes in the CNS. Has a positive effect on the bioelectrical activity of the brain.

A positive effect on the parameters of the neurological status: reduces the severity of asthenic, cephalgic, vestibuloocular, kohleovestibulyarnogo syndrome, as well as eliminates the disorder in the emotional-volitional sphere (reduces anxiety, depression). Improves cognitive and memory function and quality of life.

Indications:

Adults in the complex therapy:

• chronic cerebral ischemia stage 1-2 (cerebral atherosclerosis, hypertensive encephalopathy, stroke consequences)
  
• asthenic syndrome (malaise and fatigue).
  

Contraindications:

Individual intolerance of the drug components.

With caution:

• hypotension
  
• diseases of the gastrointestinal tract (erosive gastroduodenitis, peptic ulcer).
  

Application of pregnancy and breast-feeding:

Perhaps the use during pregnancy and lactation in the absence of allergic reactions to components.

Side effects:

Possible reactions transient headache.

Drug interactions:

Succinic acid, inosine, nicotinamide compatible with other drugs. The product is compatible with drugs stimulating hemopoiesis, antihypoxic, anabolic steroids.

Method of application and dose:

Inside, 2 table. 2 times a day half an hour before meals, not liquid, with an interval of 8-10 h, with 100 ml of water. Course duration — 25 days (100 table). Evening administration is recommended within 18 hours. the re-Appointment of the course takes place with an increase of cerebrovascular insufficiency, but no earlier than 25-30 days after the previous course.

Overdose:

Currently, overdoses of the drug have not been identified.

Special instructions:

Has no effect on concentration.

With hypertension may require adjustment of doses of antihypertensive drugs.