Expiration date: 11/2026
The composition and form of issue:
Chondroxide ointment
Ointment for external use, 100 g contains:
chondroitin sulfate 5 g
auxiliary substances: dimethyl sulfoxide (Dimexidum) petrolatum anhydrous lanolin monoglycerides distilled purified water
the aluminum tubes to 30 or 50 grams in a cardboard bundle 1 tuba.
Chondroxide gel
Gel for external use 1 g contains:
chondroitin sodium sulfate (in recalculation on 100% dry substance), 0.05 g
auxiliary substances: dimethyl sulfoxide (Dimexidum) — 0.1 g propylene glycol (1,2-PROPANEDIOL) — 0.05 g of isopropanol (isopropyl alcohol, 2-propanol), 0.05 g ethanol (ethyl alcohol) — 0.2 g sodium disulfite (sodium metabisulfite) — 0.0005 g methyl parahydroxybenzoate (nipagin, methyl paraben) — 0,0012 g parahydroxybenzoate (nipazol, propylparaben), 0.0003 g carbomer (carbopol) — 0.035 g orange flavor (flavoring food "Orange") — 0.005 g water (purified water), up to 1 g
aluminium tubes of 20, 25, 30, 35 or 40 grams in a cardboard bundle 1 tuba.
Description pharmaceutical form:
Ointment light yellow color, with the odor of dimethyl sulfoxide.
Gel yellowish, translucent, with a fruity odor.
Feature:
Acid mucopolysaccharide (sodium salt of chondroitin sulfate) of the cartilage of the trachea of cattle.
Pharmacokinetics:
Chondroxide gel is well absorbed. In accordance with the data obtained in experimental studies on mice using radiochango 3H-chondroitin sulfate, an indicator of the absorbability of chondroitin sulfate is 14%. DMSO promotes better penetration of chondroitin sulfate through the cell membrane into tissues. Chondroitin sulfate after application of the drug Chondroxide gel on the skin quickly and selectively enters into the joint to achieve Cmax after 30 min and the subsequent two-phase excretion of the drug from cartilage. The completion of the rapid phase of excretion is through 1 h after application. The retention time of the drug in the joint is 5 h.
Description pharmacological action:
Symptoms slows the progression of osteoarthritis and degenerative disc disease, has analgesic and anti-inflammatory action, stimulates regeneration of the articular cartilage, improves joint mobility and reduces swelling.
By optimal combination of the components of the gel noted the mutual strengthening of their analgesic and anti-inflammatory effects. The use of the drug symptoms can reduce the dose of NSAID taken. Symptoms ointment and gel contain natural component of chondroitin sulfate (high molecular weight mucopolysaccharide), which is involved in building cartilage.
Chondroitin sulfate improves calcium and phosphorus metabolism in the cartilage tissue, reduces the activity of enzymes that destroy cartilage, hinders the process of degeneration (destruction) of cartilage, stimulates the synthesis of glycosaminoglycans, prevents the collapse of connective tissue. This leads to a reduction of pain and increase of mobility of the affected joints.
Indications:
Degenerative-dystrophic diseases of joints and spine, including osteoarthritis and osteochondrosis of the spine (treatment and prevention).
Contraindications:
For both dosage forms:
- hypersensitivity to the drug
- damage to the skin in the area of application of the drug.
With caution:
- pregnancy
- lactation
- children's age (the efficacy and safety of not installed).
Application of pregnancy and breast-feeding:
You can't use the ointment and gel without consultation of doctor during pregnancy and lactation.
Side effects:
Allergic reactions.
Drug interactions:
Cases interaction or incompatibility with other drugs is unknown.
Method of application and dose:
Chondroxide ointment
Ointment for external use
Externally.
Applied to the skin (lesion) and is easily rubbed for 2-3 minutes (until completely absorbed) 2-3 times a day.
The course of treatment — 2-3 weeks. If necessary, repeat the treatment.
Chondroxide gel
Externally.
Applied to the skin (lesion) and is easily rubbed for 2-3 minutes (until completely absorbed) 2-3 times a day.
The course of treatment — from 2-3 weeks to 2-3 months. If necessary, repeat the treatment.
Overdose:
The cases of drug overdose were reported.
Special instructions:
Avoid contact with ointments and gel to mucous membranes and open wounds.
If on skin or clothing gel easily washed off with water without leaving residue.
You can't use the ointment and the gel without consulting a doctor in childhood.
Symptoms ointment and the gel does not cause sedation, psychomotor dysfunction, and does not affect the ability of the patient to engage in potentially hazardous activities, require increased attention and rapid mental and motor reactions.
