Expiration date: 12/2026

Structure and Composition: 

Cream for topical application 1 g 1%

active substance:

clotrimazole 10 mg

Excipients: liquid paraffin, cetomacrogol 1000 bright white soft paraffin, cetostearyl alcohol, propylene glycol, benzyl alcohol hlorokrezol EDTA disodium salt of secondary sodium phosphate dodecahydrate sodium phosphate monobasic dihydrate Purified water

in tubes of 20 g of aluminum in the paper cartons 1 tube.

Characteristic:

Canison is antifungal broad-spectrum topical.

Description of the pharmacological actions:

Antifungal effect of active principle - clotrimazole (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of the cell membrane of fungi that alters the permeability of the membrane and causes a subsequent cell lysis. Canison effective against dermatophytes, yeast and molds, as well as multi-colored depriving the pathogen (Pityriasis versicolor) and the pathogen erythrasma. Canison has antimicrobial activity against gram-positive bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis, Corynebacterium minutissimum.

Indications:

• fungal infections of the skin and mucous membranes caused by dermatophytes, molds and yeast-like fungi and pathogens sensitive to clotrimazole
  
• chromophytosis
  
• erythrasma
  
• mycoses complicated by secondary pyoderma.
  

Contraindications:

Hypersensitivity to clotrimazole or excipients.

Application of pregnancy and breastfeeding:

In clinical and experimental studies, it was found that the use of Canison during pregnancy or during breast-feeding has a negative impact on the health of the woman or the fetus (child). However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.

Application Canison directly on the breast when breast-feeding is contraindicated.

Side effect:

In rare cases, there are local allergic reactions (redness, burning, itching, tingling in the field of application of the drug).

Drug Interactions:

The local application of the drug adverse interactions with other medicines are not known.

At the same time the local administration with amphotericin B, nystatin Canison activity may decrease.

Dosage and administration:

Outwardly. The cream is applied Canison recommended 2-3 times a day with a thin layer on a pre-cleaned and dry skin lesions. For successful treatment it is important to regular use of the cream. The duration of therapy depends on the individual and the disease severity and localization. To achieve full recovery should not stop treatment cream immediately after the disappearance of acute signs of inflammation or subjective complaints. Duration of therapy should be an average of about 4 weeks. Pityriasis versicolor cured, mainly for 1-3 weeks, and erythrasma - within 2-4 weeks. When fungal diseases of the feet skin is recommended to continue treatment for about 2 weeks after the relief of symptoms of the disease.

Special instructions:

If after 4 weeks of starting treatment is not marked clinical improvement, it is necessary to conduct microbiological testing to confirm the diagnosis and rule out other causes of the disease.

If you develop increased sensitivity or irritation when using the drug, treatment should be stopped and choose another therapy.

Not recommended applying the preparation on the skin around the eyes.