Expiration date: 04/2026

The composition and form of issue:

Vaginal suppositories. 1 supp. contains active substances:

nifuratel 500 mg

nystatin 200000 IU

excipients: dimethylpolysiloxane AK1000 (Dimethicone) 

composition capsules: gelatin glycerine (glycerol) metilparagidroksibenzoat sodium parahydroxybenzoate sodium titanium dioxide iron oxide yellow 

this blister contains either 8 or 12 vaginal suppository 1 blister pack with instructions for use is placed in cardboard pack.

Feature:

Combined product for local use in gynecology, consisting of the derived nitrofuran (nifuratel) and antibiotic group of polyanov (nystatin).

Description pharmacological action:

Active against Trichomonas vaginalis and Candida fungi, protozoa, gram-positive and gram-negative microorganisms.

Clinical pharmacology:

Antimicrobial drug for local use. Having Antiprotozoal, antifungal and antibacterial action.

Nifuratel derived nitrofuran. Highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis).

Nystatin — an antifungal antibiotic of the group of Polenov. By binding to sterols in the cell membrane of fungi, violates its permeability, leading to cell death. Is highly active against fungi of the genus Candida albicans.

The combination of nystatin and nifuratel allows you to achieve a more pronounced antifungal activity and broaden the spectrum of antimicrobial action.

High efficiency and low toxicity of the components of the drug cause a wide range of its clinical application in the treatment of vaginitis of mixed etiology, in particular, the use for the prevention of fungal infections caused by specific treatment of trichomoniasis.

Macmiror complex does not violate the physiological flora, which allows to avoid the development of goiter and quickly restore Normans of the vagina.

Indications:

Complex therapy of vulvovaginal infections caused by sensitive to the drug pathogens: bacteria, Trichomonas, Candida and chlamydia.

Contraindications:

Hypersensitivity to one of the active ingredients or any subsidiary of the drug ingredient.

Application of pregnancy and breast-feeding:

Any contraindications to the use of the drug during pregnancy and lactation (breastfeeding) no.

Side effects:

In rare cases, allergic reactions such as skin rash or itching.

Drug interactions:

Not been established clinically significant drug interactions Macmiror complex with other drugs.

Method of application and dose:

Vaginally, before bed — within 8 days 1 supp. or 2.5 g of cream 1-2 times a day (using the applicator). If necessary, repeat the treatment after menstruation.

To achieve maximum therapeutic effect you should insert the suppository into the upper part of the vagina.

Suppositories is used to treat in children, it is recommended to apply vaginal cream complete with applicator (graduated syringe).

Special instructions:

A simultaneous treatment of sexual partner because of the risk of re-infection. During the period of treatment should avoid sexual contacts.

The method of using the graduated applicator: screw the graduated applicator to the tube of cream. To gain the necessary amount of cream (in accordance with scale lines indicating the number of grams), pushing the tube. Disconnect from the tube, introduced into the vagina, squeeze out the contents, pressing down on the rod.

A special nozzle allows you to enter the cream without damaging the hymen. It is necessary to remove the cannula from the upper part of the rod and screwed onto the head of the syringe from the opposite side before you enter the cream in the vagina.