Expiration date: 06/2026

Composition and form of issue:

Tablets, film-coated. 1 tablet contains:

fusidin-sodium 0.125g or 0.25 g

excipients: PVP magnesium stearinic acid sugar milk AFC acidic red 2 With castor oil titanium dioxide 

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Pharmacological action:

It has antibacterial activity against staphylococci, especially against Staphylococcus aureus and Staphylococcus epidermidis (including methicillin-resistant strains), Nocardia asteroides, Clostridium spp., meningococcus and gonococcus. Significantly less active against pneumococci and streptococci. Staphylococci resistant to penicillins, streptomycin, levomycetin, erythromycin and other antibiotics retain sensitivity to fusidin. Inactive against E. coli, Salmonella, Proteus and other gram-negative bacteria, as well as fungi and protozoa.

Pharmacokinetics:

With prolonged use, there may be a cumulative effect. When injected into well absorbed and reaches high concentrations in the blood. Penetrates the skin, subcutaneous tissue, lungs, liver, bone, pleural exudate, cartilaginous and connective tissue. Derived from the body mainly jelchew, to a lesser extent, in the urine.

Indications:

Septicaemia, pneumonia, otitis media, abscesses, phlegmons, furuncles, infected burns and wounds, soft tissue infections, osteomyelitis, etc., gonorrhea caused by benzylpenicillin-resistant strains of gonococci, or with hypersensitivity to penicillins.

Contraindications:

Hypersensitivity.

Application for pregnancy and breastfeeding:

If necessary, use during pregnancy should assess the expected benefit to the mother and the potential risk to the fetus, because it displaces bilirubin from its Association with blood plasma proteins, increasing the risk of nuclear jaundice.

Side effect:

Abdominal pain, nausea, vomiting, diarrhea, caused by the local irritant effect of the drug on the mucous membrane of the gastrointestinal tract allergic phenomena (redness of the oral mucosa and pharynx, swallowing pain, skin rashes).

Drug interaction:

Other antibiotics significantly increase the effect of fuzidin-sodium for the microorganisms sensitive to it.

Method of application and doses:

Inside, after eating. Adults single dose is usually-0, 5 g, daily-1, 5 g in 3 admission at intervals of 8 h. the Average duration of the course-7-14 days, with osteomyelitis-2-3 weeks. Children are prescribed at the rate of 40-60 mg/kg, and in severe disease — up to 80 mg /kg / day.

Special instruction:

In severe disease and the need for long-term treatment, a combination with semi-synthetic penicillins or tetracyclines is recommended, which increases efficiency and prevents the emergence of resistant microorganisms.

To prevent and reduce side effects from the gastrointestinal tract, the drug is taken with liquid food or milk.