• Bezak (Biperiden) 2mg 50 tablets

Expiration date: 11/2024

Pharmacological action

Pharm group: Antiparkinsonian drug, an inhibitor of cholinergic transmission in the CNS

Formdata: does Central n-holinoretseptora and peripheral m-cholinergic transmission of excitation; the latter provides a myotropic antispasmodic effects.

Pharmacokinetics: Cmax (1,01–of 6.53 ng/ml) achieved through 0.5–2 h, the equilibrium concentration of the ingestion of 2 mg 2 times/day — using a 15.7–40.7 per hours Associated with the plasma protein up to 91-94%. Clearance in plasma is 11.6 ml/min/kg. Completely metabolized. The main metabolites — bicycloheptane and piperidine. The elimination is carried out in two phases with T1/2 1,5 h in the first phase and 24 h in the second. Excreted by the kidneys and gastrointestinal tract. Bioavailability when administered in the gastrointestinal tract is 33%. Passes into breast milk.

Reduces muscle rigidity, tremor and autonomic disorders, to a lesser extent, the symptoms of akinesia.

Testimony

— syndrome of parkinsonism;

— extrapyramidal symptoms (tremor, muscle rigidity, torsion dystonia, local forms of dystopia, including paroxysmal dyskinesia, hyperkinesis trochaic, Tiki various forms, myoclonia and hyperkinesias, dystonia of muscles of extremities, trunk, neck, face, akinesia, akathisia) caused by neuroleptics or similarly acting drugs.

Contraindications

— hypersensitivity to the drug Bezak;

— ileus;

— hypertrophy of the prostate with urinary retention;

— angle-closure glaucoma;

mechanical narrowing or obstruction of the digestive tract;

— children up to age 18 years (data on the effectiveness and safety of the drug in children do not exist).

With caution:

Elderly patients, myasthenia gravis, arrhythmia, patients with a tendency to convulsive seizures, including history of patients with arrhythmia, prostate hypertrophy, congestive heart failure, ischemic heart disease, arterial hypertension, ileostomy/colostomy, and epilepsy.

Composition

1 tablet contains biperiden hydrochloride 2 mg

Excipients: cellulose microcrystalline - 192 mg, carboximetilkrahmal sodium 5 mg, magnesium stearate - 1 mg.

Method of application and doses

Inside. Pills Bezak should be taken during or after meals with some liquid.

The syndrome of parkinsonism adults the initial dose is 1 mg 1-2 times/day (1/2 tab.). The dose can be increased to 2 mg (1 tab.) every day. The maintenance dose is 3-16 mg/day (1/2-2 tab. 3-4 times/day). The maximum daily dose is 16 mg (8 tablets). The total daily dose should be evenly spread doses during the day.

When xtrapremium symptoms caused by neuroleptics or similarly acting drugs for adults, the initial dose depending on the severity of symptoms is 1-2 mg (1/2-1 tab.) 1-4 times/day as proof neuroleptic therapy. Disposable dose depending on the severity of symptoms can increase to 4 mg and the daily dose up to 16 mg.

Undesirable side effects from the gastrointestinal tract can be reduced by taking the tablet immediately after eating. The duration of treatment depends on the nature and course of the disease. If you cancel biperiden, the dose should be gradually reduced.

Bezak
(Biperiden)
2mg
50
tablets