Expiration date: 03/2026
Ointment for external application: Homogeneous ointment white or nearly white.
Characteristic:
Mupirocin - an antibiotic that is produced by fermentation of the microorganism Pseudomonas fluorescens.
Pharmachologic effect:
Transfer Suppresses isoleucine tRNA synthetase, which leads to the cessation of protein synthesis in the bacterial cell. Due to the specific mechanism of action and unique chemical structure, mupirocin shows no cross-resistance with other antibiotics (when used correctly the risk of drug-resistant strains of the small).
Pharmacokinetics:
It is characterized by poor permeability through intact skin. In the case of absorption through damaged skin is metabolized to microbiologically inactive Moniev acid and rapidly excreted by the kidneys.
Description of the pharmacological actions:
The minimum inhibitory concentrations has bacteriostatic and in higher concentrations - bactericidal properties. The spectrum of in vitro antibacterial activity:
- Gram-positive aerobes: Staphylococcus aureus (including strains resistant to methicillin, and beta-lactamase-producing), Staphylococcus epidermidis and other coagulase Staphylococcus spp, Streptococcus spp..
- Gram negative anaerobes: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis
- Insensitive: Corynebacterium spp, species of the family Enterobacteriaceae, non-fermentative Gram-negative rods, of Micrococcus, anaerobes..
Testimony:
Intranasal ointment: carriage of staphylococci (including multidrug-resistant strains of Staphylococcus aureus and methicillin-resistant).
Dermatological ointment: the treatment of primary skin infections - impetigo, folliculitis, abrasions (including furuncle of external auditory canal and the ear), ecthyma secondary infections of the skin - infected eczema, infected injuries (scrapes, insect bites), minor (not requiring hospitalization) wounds and burns prevention of wound infection after minor cuts, wounds and minor abrasions.
Contraindications:
Hypersensitivity to any component of the ointment.
Precautions: Pregnancy and lactation.
Application of pregnancy and breastfeeding:
Use with caution due to the lack of data supporting the safety of the drug in these periods. If Baktroban prescribed for the treatment of cracked nipples, the nipples before feeding should be washed thoroughly.
Side effect:
Very rarely - itching, burning, soreness and dryness of the skin at the site of application of rare - allergic skin reactions in rare cases - systemic allergic rhinitis (when using a nasal ointment).
Drug Interactions:
No posts.
Dosage and administration:
Intranasal, topically. Ointment intranasal: applied to the inner surface of the nostril 2-3 times a day for 5-7 days.
Ointment for external use: adults, children, and elderly patients a small amount applied to the affected area 2-3 times a day, impose aseptic bandage, if necessary, a course of treatment - up to 10 days.
When liver failure is used a standard dose.
Renal failure - see "Precautions"..
Baktroban ointment can not be combined with other drugs due to its dilution risk, reducing antibacterial activity and stability.
Overdose:
Data not available.
Precautionary measures:
Ointment 2% can not be used outdoor for the treatment of eye diseases, intranasally, in the drainage area.
Avoid contact with eyes ointment. In case of contact with the eyes should be thoroughly rinsed with water to remove residues of ointment.
Use in renal impairment: in elderly patients there is no limitation for use, except in cases where at the time of treatment there are conditions for absorption of polyethylene glycol, which is part of ointments, and symptoms of moderate to severe renal insufficiency. Polyethylene glycol can be absorbed through the surface of the wound or other skin damage and excreted through the kidneys. Dermatological ointment (polyethylene glycol) can not be used for conditions involving increased absorption of polyethylene glycol, particularly in moderate or severe renal failure.
In rare cases of allergic reactions or significant irritation of the skin, treatment should be discontinued, the affected area be washed with water to remove any remaining ointment and appoint an alternative anti-infectious therapy.
Special instructions:
After application to the skin should wash your hands thoroughly. Long-term appointment Baktroban ointment may result in overgrowth of non-susceptible organisms.
Adverse effect on the ability to drive a car / not observed mechanisms.
