Expiration date: 08/2025

Anthelmintic drug broad-spectrum, most effective against Enterobius vermicularis, Trichuris trichura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, the species Trichinella spiralis, the species Trichinella nativa, the species Trichinella nelsoni. Causing irreversible disruption of glucose utilization, depletes glycogen reserves in the tissues of helminths, prevents the synthesis of cellular tubulin, and inhibits the synthesis of adenosine triphosphate (ATP).

Pharmacokinetics:

Practically not absorbed in the intestine. After taking the drug in a dose of 100 mg twice a day for three consecutive days, the concentration in the blood plasma of mebendazole and its metabolite (2-amino derivative) does not exceed 0,03 µg/ml and 0.09 µg/ml, respectively. The link with proteins plasma-90 %. Unevenly distributed to organs, accumulates in adipose tissue, liver, larvae of helminths. Metabolized in the liver to 2-amino derivatives, which do not possess anthelmintic activity. The half-life is 2.5-5.5 hours. More than 90% of the dose is removed through the intestine unchanged. The absorbed part (5-10 %) is excreted by the kidneys.

Indications for use of the drug

• enterobiasis
• ascariasis
• hookworm disease
• strongyloidiasis
• trichocephalosis
• trichinosis
• taeniasis as if monoinvasion and mixed helminthiasis
• echinococcosis (if surgical treatment is impossible).

Recommended use

Inside with a little water. Adults and children over 3 years.

In enterobiosis-once for 100 mg / day (1 tablet), the course of treatment is 1 day. Since reinfection with enterobiosis occurs quite often, the treatment should be repeated after 2 and 4 weeks. It is recommended to carry out simultaneous treatment of all family members.

Ascariasis, trihozefaleze, hookworm and mixed helminth infections: 200 mg/day (1 tablet morning, 1 tablet evening), the course of treatment 3 days.

When teniasis, strongyloidiasis. Adults: 400 mg / day (2 tablets in the morning, 2 tablets in the evening), 3 days of treatment. Children over 3 years: 200 mg / day (1 tablet in the morning, 1 tablet in the evening), 3 days of treatment.

With echinococcosis. Adults and children over 14 years: in the first three days of 500 mg 2 times a day, in the next 3 days, the dose is increased to 500 mg 3 times a day, in the future, the dose is increased to 1000-1500 mg 3 times a day. The average duration of treatment of echinococcosis caused by Echinococcus granulosis is 4-6 weeks, caused by Echinococcus multilocularis – up to two years.

With trichinosis in the 1st day 3 times a day for 200-300 mg, on the 2nd day 4 times a day for 200-300 mg, and from 3 to 14 day – 3 times a day for 500 mg.

Side effect

Allergic reactions: skin rash, urticaria, angioedema, Steven-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions.

From the hematopoietic organs: neutropenia.

From the digestive system: nausea, vomiting, abdominal pain, diarrhea, increased activity of "liver" transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the nervous system: dizziness, headache, drowsiness, convulsions.

From the urinary system: hypercreatinemia, glomerulonephritis (when used in high doses for a long time).

Other: hair loss (when used in high doses for a long time).