Expiration date: 05/2025
Form release
Tablets, film-coated
Pharmacological action
Antiviral drug, a synthetic carbocyclic nucleoside analogue. Inside the cell, abacavir is converted with the participation of cellular enzymes in the active metabolite of carbovir triphosphate. Carbovir triphosphate is an analogue of deoxyguanosine-5' - triphosphate (dgtf). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase, due to competition with the natural substrate dgtf and violation of its integration into viral DNA. The loss of the 3'-OH group in the embedded nucleoside analog prevents the formation of 5'- and 3'-phosphor ester bonds required for DNA chain elongation. As a result, the growth of viral DNA stops.
Indications
Treatment of HIV infection (as part of combination therapy).
Composition
1 tablet, film coated 600 mg, contains:
Active ingredient: abacavir sulfate 351,4 mg, in terms of abacavir 300 mg.
Excipients: sodium carboxymethyl starch 35 mg, silicon dioxide colloidal 7 mg, magnesium stearate 7 mg, povidone K-30 28 mg, microcrystalline cellulose 291,6 mg. composition of the film shell: Opadray II yellow 22 mg, including: hypromellose (hydroxypropylmethylcellulose) 7,48 mg, lactose monohydrate 6,16 mg, macrogol (polyethylene glycol) 2,64 mg, titanium dioxide 4,62 mg, dye iron oxide yellow 1.1 mg.
Dosage and administration
The drug abacavir Canon is taken orally, regardless of food intake. The drug should be prescribed by a doctor with experience in treatment
hiv infection. To ensure the accuracy of the dosage of the drug, the tablet is recommended to be swallowed completely without division, but as an alternative, division and grinding of tablets with the addition of a small amount of semi-solid food or liquid is allowed. All amounts of the mixture must be taken orally immediately.
Adults and children weighing at least 25 kg
The recommended dose of Abacavir Canon-600 mg / day. The drug is prescribed at a dose of 300 mg (1 tablet of 300 mg or ½ tablet of 600 mg, break exactly at risk) 2 times a day or 600 mg (2 tablets of 300 mg or 1 tablet of 600 mg) 1 time per day.
