Expiration date: 02/2026
Group: Antispasmodic agent
Active ingredients: Drotaverine
Dosage form: capsules, injection solution, tablets, coated tablets
Pharmacological action:
Myotropic antispasmodic. According to the chemical structure and pharmacological properties close to papaverine, but has a stronger and longer-lasting effect. Reduces Ca2+ in smooth muscle cells (inhibits PDE, leads to the accumulation of intracellular camp). Reduces the tone of smooth muscles of internal organs and intestinal peristalsis, dilates blood vessels. Does not affect the autonomic nervous system, does not penetrate the Central nervous system. The presence of a direct effect on smooth muscles can be used as a antispasmodic in cases where drugs are contraindicated from the group of m-cholinoblockers (angle-closure glaucoma, prostatic hypertrophy). When the/in the beginning of the effect-through 2-4 minutes, the maximum effect develops after 30 minutes.
Indications: Prevention and treatment: spasm of smooth muscles of internal organs (renal colic, biliary colic, intestinal colic, biliary dyskinesia and gall bladder hyperkinetic type, cholecystitis, post-cholecystectomy syndrome), pyelitis, spastic constipation, spastic colitis, proctitis, tenesmus, pylorospasm, gastroduodenitis, gastric ulcer and 12 - duodenal ulcer (in phase exacerbations, as part of complex therapy-to relieve pain of a spastic nature). Endarteritis, spasm of peripheral, cerebral and coronary arteries. Algomenorrhea threatening miscarriage, premature birth threatening spasm cervix during labor, prolonged opening Zev, postpartum contractions. When carrying out some instrumental studies holetsistografii.
Contraindications: Hypersensitivity, severe hepatic and renal failure,CHF, AV blockade II-III art., cardiogenic shock, hypotension.C caution. Expressed atherosclerosis of coronary arteries, closed-angle glaucoma, prostatic hyperplasia, lactation, pregnancy (I trimester).
Side effects: Dizziness, heartbeat, feeling of heat, increased sweating, decreased blood PRESSURE, allergic skin reactions. At/in the introduction, collapse, AV blockade, arrhythmia, oppression breathing centre.
Overdose:
Symptoms: in large doses, it violates the atrioventricular conduction, reduces the excitability of the heart muscle, can cause cardiac arrest and paralysis of the respiratory center.
Dosage and administration: Drotaverine is taken orally, adults-40-80 mg 3 times a day,/m, p / C - 40-80 mg 1-3 times a day. For the relief of hepatic and renal colic - in/in slowly, 40-80 mg cramps in peripheral vessels of the drug can enter in/and. Children under 6 years - at a dose of 10-20 mg, the maximum daily dose of 120 mg, 6-12 years of single - 20 mg, maximum daily dose of 200 mg, the multiplicity of purposes - 1-2 times a day.
Special instructions: in the treatment of gastric ulcer and duodenal ulcer is used in combination with other anti-ulcer drugs. During treatment, it is necessary to refrain from driving vehicles and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions (within 1 hour after parenteral, especially in/in the introduction).
Interaction: while the use of drotaverine may weaken the antiparkinsonic effect of levodopa. Increases the effect of papaverine, bendazole and other antispasmodics (including m-holinoblokatorov), lowering blood PRESSURE, caused by tricyclic antidepressants, quinidine and procainamide. Phenobarbital increases the severity have spasmolytic action drotaverina. Spazmogennoe reduces the activity of morphine.
