Expiration date: 07/2026

Structure and Composition:

Vaginal Suppositories. 1 supp. contain ketoconazole 400 mg

Excipients: butylhydroxyanisole

Basis: Macrogol 1500 (polyethylene 1500), macrogol 400 (polyethylene 400) - a sufficient amount to obtain a suppository weighing 3 g

in blisters 5 pcs. a stack of cardboard packaging 1 or 2.

Description pharmaceutical form:

Suppositories white, white with yellowish or grayish, or Valium a color shade, Valium forms. Supposed Valium surfaces.

Characteristic:

Ketoconazole - derivative imidazoldioksolana.

Pharmacokinetics:

Systemic absorption in intravaginal application, insignificant.

Description of the pharmacological actions:

Has fungicidal and fungistatic against dermatophytes (Trichophyton spp., Epidermophyton floccossum, Microsporum spp.) And yeast (Candida spp., Pityrosporum spp.). The mechanism of action is inhibition of ergosterol biosynthesis and modification of the lipid composition of fungal membrane. It is active against streptococci and staphylococci.

Indications:

acute and chronic recurrent vaginal candidiasis

the prevention of fungal infections of the vagina at a reduced resistance of the organism and during treatment with antibacterial agents and other drugs that violate the normal microflora of the vagina.

Contraindications:

Hypersensitivity to the drug

I trimester pregnancy.

Carefully:

Pregnancy II-III trimester

lactation

Children up to age 12 years.

Side effect:

Hyperemia and irritation of the vaginal mucosa, vaginal itching.

Allergic reactions: skin rash, urticaria.

Drug Interactions:

Negative interactions with other drugs is not known and can not be expected, because resorptive capacity ketoconazole low.

Dosage and administration:

Intravaginal releasing suppository from the contour of the package. In the "supine" deep - 1 supp. daily for 3-5 days depending on the disease.

In chronic candidiasis - 1 supp. 10 days.

Instructions for use:

1. Remove the suppository of contour packaging (packaging equipped with special flaps that allow you to easily and quickly extract suppository without damaging it).

2. Enter the suppository deep into the vagina, in the "supine".

3. Do not interrupt the course of treatment on their own, if any symptoms have disappeared, since incomplete treatment can lead to a transition of the disease into a chronic form.

Special instructions:

The benefits of treatment with vaginal suppositories Livarol:

• Speed ??of action, due to the introduction of drugs into the nidus of inflammation
  
• Pronounced effect associated with the creation of a high concentration of active substances in the vagina
  
• The minimum number of side effects (drug absorption when applied topically minimum)
  
• Ease of use
  
• Recovery in the short term (3-5 days).
  

In rare cases, allergic reactions (redness of the penis) with a partner.

To reduce the risk of recurrence of the disease to the simultaneous treatment of sexual partners.

Recommendations for the prevention of a possible recurrence of the fungal infection:

• Should be preferred loose clothing and underwear made of cotton
  
• Is not recommended for a long time in a wet bathing suit, because warm moist environment conducive to the development of fungi
  
• Only private towel should be used, as wet towel can keep infection
  
• During the advisable to wipe movements hygiene front to back to avoid skidding of bacteria from the anus to the vagina
  
• Should not eat a lot of sweets, because under the influence of their vaginal pH may change, which may lead to the activation of the fungus
  
• You need to eat sour milk products containing Lactobacillus
  
• Recommended in the case of antifungal antibiotics in connection with the treatment of other disease
  
• It is necessary to abstain from sexual intercourse during the treatment of fungal infections.