Expiration date: 02/2026
Composition
1 tablet contains:
Active ingredient: 250 mg acetazolamide
Excipients: potato starch, talc, sodium starch glycolate.
Packaging
30 pcs.
pharmachologic effect
Diacarb - a weak diuretic. It inhibits the enzyme carbonic anhydrase in the proximal convoluted tubules of the nephron increases the urinary excretion of Na + and K +, bicarbonate, does not affect the excretion of ions Cl, basified urine. It violates the acid-base status (CBS) (metabolic acidosis). Inhibition of carbonic anhydrase of ciliary body reduces the secretion of aqueous humor and reduce intraocular pressure. Inhibition of carbonic anhydrase activity in the brain causes the presence antiepileptic activity. Duration of action - up to 12 hours.
testimony
Edematous syndrome (mild to moderate severity, in combination with alkalosis), glaucoma (primary and secondary, acute attack), epilepsy (as part of combination therapy), mountain sickness.
Contraindications
Hypersensitivity to the drug Diacarb, acute renal failure, hepatic failure, hypokalemia, acidosis, gipokortitsizm, Addison's disease, uremia, diabetes, pregnancy, lactation.
Be wary - swelling of liver and kidney origin, receiving high doses of acetylsalicylic acid.
Dosing and Administration
The drug is taken orally, strictly on prescription.
edematous syndrome
Early treatment of 250 - 375 mg (1 - 1 ½ tablet) once a day 1 - morning.
The maximum diuretic effect is achieved while taking the drug every other day or two days in a row, and then - a one-day break.
Applying Diacarb, you must continue the treatment recommended by circulatory failure, for example, digitalis glycosides, to comply with the restriction of salt intake in the diet and replenishing the lack of potassium.
Glaucoma
Adults are usually given:
with open-angle glaucoma: 250 mg (1 tablet) 1-4 times a day.
Dosages of more than 1000 mg (4 tablets) does not increase the efficacy of treatment.
secondary glaucoma with 250 mg (1 tablet) every 4 h.
In some patients, the effectiveness of the drug is observed after a dose of 250 mg (1 tablet) twice a day 2 (in short-term therapy).
acute glaucoma attacks of 250 mg (1 tablet) four times a day.
Children with glaucoma attacks of 10-15 mg / kg body weight per day in 3 - 4 divided doses.
Epilepsy
Adults: 250 - 500 mg / day in a single step for 3 days at 4 day interval.
Children: 4-12 months 50 mg / day for 1 - 2 doses, 2-3 years: 50 - 125 mg / day in 1-2 reception 4-18 years: 125 - 250 mg once in the morning.
With simultaneous application of Diamox with other anticonvulsant drugs used in early treatment of 250 mg (1 tablet) 1 time per day, gradually increasing the dose if necessary.
In children, the dose should not be used higher than 750 mg per day.
mountain sickness
Recommended use of the drug at a dose 500 - 1000 mg of (2 - 4 tablets) daily in equal doses.
In the case of rapid ascent - 1000 mg (4 tablets) daily in equal doses.
The drug should be used for 24 - 48 hours before the ascent, and in case of the onset of symptoms - to continue treatment for the next 48 hours or longer if necessary.
When you miss a dose, the next time the reception is not to increase the dose.
Side effects
Hypokalemia, muscle weakness, cramps, skin flushing, paraesthesia, tinnitus, anorexia, metabolic acidosis, pruritus, myopia, urticaria. With prolonged use - nephrolithiasis, hematuria, glycosuria, hemolytic anemia, leukopenia, agranulocytosis, disorientation, disturbance of the sense of touch, drowsiness, nausea, vomiting, diarrhea, allergic reactions, paresthesia.
special instructions
In the case of the appointment of the drug for more than 5 days at high risk of developing metabolic acidosis.
Prolonged use should be monitored indicators vodnoelektrolitnogo balance, peripheral blood picture, CBS.
Drug interactions
Enhances manifestations of osteomalacia, caused by taking anti-epileptic drugs.
Combination with other diuretics and theophylline enhances the diuretic effect.
Acidifying diuretics attenuate the severity of the diuretic effect.
Increases toxicity of salicylates, digitalis drugs, carbamazepine, ephedrine, non-polarizing muscle relaxants.
Overdose
In the case of drug poisoning should immediately seek medical attention.
No cases of drug overdose or acute poisoning. Symptoms of overdose - increased side effects.
Treatment: symptomatic.
Storage conditions
Store in a dry place, protected from light and the reach of children, at a temperature below 25 ° C.
Shelf life
5 years.
