Expiration date: 02/2025
Composition and form of issue:
Powder for preparation of intravenous solution 1 FL.
active substance:
amoxicillin (in the form of sodium salt) 500 mg
clavulanic acid (in the form of potassium salt) 100 mg
in vials in a pack of cardboard 5 bottles.
Powder for preparation of intravenous solution 1 FL.
active substance:
amoxicillin (in the form of sodium salt) 1000 mg
clavulanic acid (in the form of potassium salt) 200 mg
in vials in a pack of cardboard 5 bottles.
Method of application and doses:
Adults and children over 12 years of age or weighing more than 40 kg: 1200 mg of the drug (1000 + 200 mg) with an interval of 8 h, in the case of severe infection — with an interval of 6 h.
Children aged from 3 months to 12 years: 30 mg / kg (in terms of the whole Amoxiclav) with an interval of 8 h, in the case of severe infection — with an interval of 6 h.
Children under the age of 3 months (premature and perinatal): 30 mg / kg (based on the whole Amoxiclav) every 12 hours.
In the postperinatal period: 30 mg / kg (based on the whole Amoxiclav) every 8 hours.
Every 30 mg of Amoxiclav contains 25 mg of amoxicillin and 5 mg of clavulanic acid.
Prophylactic doses in surgical interventions: 1200 mg in introductory anesthesia (with a duration of less than 2 hours). With longer operations-1200 mg up to 4 times during the day.
For patients with renal insufficiency dose and/or interval between drug administration should be adjusted depending on the degree of insufficiency:
| Creatinine Cl | Dose and / or interval between injections |
| >0, 5 ml / s (30 ml/min) | Dose correction is not required |
| 0, 166-0, 5 ml / s (10-30 ml/min) | The first dose is 1200 mg (1000 + 200 mg), and then 600 mg (500+100 mg) in / in every 12 hours |
| <0, 166 ml / s (less than 10 ml/min) | The first dose-1, 2 g (1000 + 200 mg), and then 600 mg (500 + 100 mg) in / in every 24 hours |
| anuria | The dosing interval should be increased to 48 hours or more |
Since 85% of the drug is removed by hemodialysis, at the end of each hemodialysis procedure it is necessary to enter the usual dose of Amoxiclav. In peritoneal dialysis, dose adjustment is not required.
The course of treatment is 5-14 days. The duration of treatment is determined by the attending physician. When reducing the severity of symptoms for the continuation of therapy, it is recommended to switch to oral forms of the drug Amoxiclav.
Preparation of solutions for injection. Dissolve the contents of the vial in water for injection: 600 mg (500 +100 mg) — 10 ml of water for injection or 1200 mg (1000 +200 mg) — 20 ml of water for injection. The solution is administered slowly (over 3-4 min.)
Preparation of solutions for in / infusion. For infusion Amoxiclav need further dilution: prepared solutions containing 600 mg (500 +100 mg) or 1200 mg (1000 +200 mg) of the drug should be diluted in 50 ml or 100 ml infusion solution, respectively. Duration of infusion-30-40 minutes.
When using the following liquids in the recommended volumes in infusion solutions, the necessary concentrations of the antibiotic remain:
| ???????????? ???????? | Period of stability, h | |
| at 25 °C | at 5 °C | |
| Water for injection | 4 | 8 |
| A solution of sodium chloride 0, 9% for I/V infusion | 4 | 8 |
| Normal saline and ringer's lactate for on/in infusions | 3 | |
| A solution of potassium chloride and sodium chloride for on/in infusions | 3 | |
Amoxiclav is less stable in infusion solutions containing glucose, dextran or bicarbonate.
Amoxiclav should be administered within 20 minutes after the preparation of solutions for on/in the introduction. Only clear solutions should be used. Prepared solutions should not be frozen.
Comment:
Before prescribing the drug, please read the full instructions for use.
