Expiration date: 05/2026
Pharmacological action
Cephalosporin antibiotic of the second generation of broad spectrum. Has a bactericidal effect by inhibiting the synthesis of bacterial cell wall. Cefuroxime acetylates membrane-bound transpeptidases, thus disrupting the cross-linking of peptidoglycans necessary to ensure the strength and rigidity of the cell wall.
Highly active against gram-negative bacteria: Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Proteus mirabilis, Neisseria gonorrhoeae, Enterobacter spp.
It is also active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp.
Inactive for Pseudomonas spp. most strains of Enterococcus spp., many Enterobacter cloacae strains, methicillin-resistant Staphylococcus spp strains. and Listeria monocytogenes.
Resistant to ?-lactamase.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to cefuroxime, including abdominal and gynecological infections, sepsis, meningitis, endocarditis, urinary tract infections, respiratory tract infections, bone and joint infections, skin and soft tissue infections. Prevention of postoperative infectious complications in operations on the abdominal organs, pelvis, heart, lungs, esophagus, vessels, orthopedic surgery.
Mode of application and dosage
Set individually, taking into account the severity and localization of infection susceptibility. Used inside, in/m or/V. At the oral single dose for adults is 250-500 mg, children 125-250 mg, the multiplicity of reception 2 times/day.
In case of parenteral administration, the single dose for adults is 0.75-1.5 g 3 times / day. Depending on the etiology of the disease is used 1.5 g once or 750 mg 2 times every 8 h. Children under the age of 3 months - 10-50 mg/kg/day, frequency of administration 2-3 times over 3 months - 15-80 mg/kg/day, frequency - 2-3 times.
Patients with impaired renal function dosing regimen is established taking into account the values of CC.
The maximum daily dose for adults is 6 g.
Side effect
From the digestive system: nausea, vomiting, diarrhea, transient increase in liver transaminases, cholestatic jaundice, hepatitis, pseudomembranous colitis.
Allergic reactions: skin rash, itching, eosinophilia; rare - angioedema.
From the hematopoietic system: long-term use in high doses may change the picture of peripheral blood (leukopenia, neutropenia, thrombocytopenia, hemolytic anemia).
From the side of the blood clotting system: hypoprothrombinemia.
From the urinary system: interstitial nephritis.
Effects, due to chemotherapeutic effect: candidiasis.
Local reactions: phlebitis (at/in the introduction), pain at the injection site (at/m introduction).
Contraindications
Hypersensitivity to cefuroxime and other cephalosporins.
