• Andipal

Expiration date: 06/2024

The composition and form of issue: 

Tablets, 1 tablet contains:

analginum 0, 25 g

dibazolum 0, 02 g

phenobarbital 0, 02 g

papaverine hydrochloride 0. 02 g

auxiliary substances: starch talc stearic acid — a sufficient amount to obtain tablets of 0, 37 g 

in a contour bezgyachakova packing 10 PCs

Description pharmaceutical form:

Tablets white or white with a faint yellow tint.

Description pharmacological action:

Andipal, as an antispasmodic used for cramps of the peripheral vessels and cerebral vessels. Reducing the CSO, acting on the arterioles, the drug lowers blood pressure, improves the collateral circulation. The combination of antispasmodics myotropic (papaverine and Dibazol hydrochloride) analgin potentiates the analgesic effect in headache, migraine. The presence of the drug phenobarbital contributes to the sedative effect and increase the action of other components.

Indications:

Pain syndrome associated with moderately severe peripheral vascular spasm of cerebral vessels:

  • mild forms of hypertension
  • migraine.

Contraindications:

  • hypersensitivity to the components included in the composition of the drug
  • the deficit glukozo-6-fosfatdegidrogenaza
  • violation of AV conduction
  • severe violations of the liver and kidneys
  • diseases of the blood
  • myasthenia gravis
  • porphyria
  • pregnancy (I trimester)
  • breastfeeding.

Side effects:

Sometimes nausea, constipation, allergic reactions (up to anaphylactic shock). Long-term use of the drug inhibitory effect on the blood due to the presence of dipyrone (leukopenia, rarely agranulocytosis, thrombocytopenia). Phenobarbital present in the drug may have a sedative effect, sometimes you may experience ataxia, depression (especially in elderly and debilitated patients).

Drug interactions:

Pharmacological: combination with nitrates (Nitroglycerin, Nitrosorbid, Sustak, etc.), CCB (Nifedipine, Corinfar), amiodarone, beta-blockers (Inderal, metoprolol, oksprenolol, talinolol, etc.), ganglionic (pentamine, etc.), diuretics (Furosemide, Hydrochlorothiazide, etc.), myotropic antispasmodics (dipyridamole, aminophylline, etc.) enhances the hypotensive effect Antipala.

The combined use of direct agonists (epinephrine, norepinephrine, etc.) and indirect (ephedrine) type of action n - and m-, n-cholinomimetics (nicotine, acetylcholine, etc.), analeptics (camphor, Sulfokamfokain, Kordiamin, bemegride, lobeline, cytisine, etc.), tonics (ginseng, Eleutherococcus extract, Rhodiola extract, etc.) and Andipal reduces hypotensive effect of the latter.

Pharmacokinetic: combined use of activated carbon, binders and enveloping means decreases the absorption of the drug in the digestive tract.

Method of application and dose:

Inside. Adults — 1-2 table. 2-3 times a day. The course of treatment — 7-10 days.

The ineffectiveness of treatment the drug should be replaced or combined with other drugs (to achieve a hypotensive effect).

Overdose:

Symptoms: in overdose occurs severe drowsiness, dizziness, collaptoid state.

Treatment: first aid — gastric lavage, administration of activated charcoal. Symptomatic therapy.

Special instructions:

Use caution when working with machinery.

With prolonged use is necessary to control blood picture.

Andipal