Expiration date: 05/2026

Composition and form of issue:

Tablets, film-coated. 1 tablet contains:

Pyrantel embonate (in terms of Pyrantel base) 125 or 250 mg

excipients: corn starch sodium starch magnesium glycolate stearate methylhydroxypropylcellulose polyethylene glycol 400 monostearate propylene glycol titanium dioxide dye yellow-orange based aluminum oxide lacquer-in the amount required for 1 tablet coated

in a contour cell package 3 (250 mg) or 6 (125 mg) PCs.in a pack of cardboard 1 package.

Suspension for oral administration. 100 ml contains:

Pyrantel embonate (in terms of Pyrantel base) 5 g

excipients: sorbitol kristallizuetsya 70% glycerol Polysorbate 80 soy lecithin privideniy excipient citric acid and dehydrated sodium benzoate emulsion silicone flavouring blackcurrant caramel of aluminium and colloidal magnesium silicate purified water

in bottles of brown glass 15 ml (complete with measuring spoon 2, 5 ml) in a pack of cardboard 1 bottle.

Description of dosage form:

Tablets: oblong tablets coated with a yellow-orange color, with a risk on one side. The Matochkin: core lemon yellow.

Suspension: liquid opaque homogeneous suspension of light yellow color with a characteristic smell of black currant and caramel. Precipitation may occur. With manual stirring, the particles easily pass into the suspension.

Pharmacological action:

Causes neuromuscular blockade in susceptible helminths and provides them with exile without excitation and stimulation of the migration of the affected worms. In the lumen of the intestine is effective against Mature and immature sensitive helminths of both sexes.

Pharmacokinetics:

Practically not absorbed from the gastrointestinal tract. After a single oral dose of 12, 5 mg / kg concentration in plasma (0, 05-0, 13 mg/ml) is maintained for 1-3 no.partially Metabolized in the liver to N-methyl-1, 3-propanediamine. Excreted through the intestine - about 93% unchanged, 7% — kidneys unchanged or as a metabolite.

Description of pharmacological action:

Highly effective against infestations caused by pinworms (Enterobius vermicularis), roundworm (Ascaris lumbricoides), hookworm (Ancylostoma duodenale and Necator americanus).

Indications:

Ascariasis, enterobiasis (pinworm infection), hookworm disease.

Contraindications:

Hypersensitivity to Pyrantel and other components of the drug, myasthenia gravis, liver failure.

With caution-children under 6 months.

Use during pregnancy and breast-feeding:

During pregnancy, use in case of emergency. At the time of treatment should stop breastfeeding (the drug penetrates into the mother's milk).

Side effect:

From the digestive tract: sometimes-nausea, vomiting, gastralgia, diarrhea, loss of appetite, a slight and short-term increase in the activity of hepatic transaminases.

Allergic reactions: itching, urticaria, exanthema.

From the nervous system and sensory organs: headache, dizziness, feeling tired, drowsiness or insomnia, hearing impairment, hallucinations, confusion, paresthesia, hyperthermia.

Drug interaction:

Not recommended simultaneous appointment with levamisole and piperazine. Increases the concentration of theophylline in plasma.

Dosage and administration:

Inside, at any time of the day, without taking laxatives, not necessarily on an empty stomach.

The tablets are intended for adults and children over 6 years.

Only suspension is recommended for children under 6 years of age. The suspension is designed for children weighing more than 12 kg. Suspension, shake before use.

1 ml of the suspension contains 50 mg of Pyrantel base, 1 scoop (2, 5 ml) - 125 mg of Pyrantel base.

Pinworms and ascarids: in the treatment of enterobiosis and ascaridosis, the drug is prescribed once in the recommended dose.

The usual dosage is 12, 5 mg / kg once:

• children under 6 years — 1 scoop suspension per 10 kg body weight
• children over 6 years — 1 scoop suspension or 1 table. 125 mg per 10 kg body weight
• adult body weight less than 75 kg - 6 measuring spoons or 6 table. 125 mg, or 3 table. 250 mg each
• adults weighing more than 75 kg - 8 scoops of suspension or 8 table. 125 mg, or 4 table. 250 mg each.

To prevent re-infection, it is recommended to repeat the drug after 3 weeks.

Hookworm in endemic areas, in case of infestation Necator americanus or heavy ?????????Ankylostoma duodenale — 25 mg/kg/day (in 1 or 2 doses) for 2-3 days:

• children-250 mg per 10 kg of body weight daily
• adults weighing less than 75 kg-1, 5 g per day
• adults weighing more than 75 kg-2 g per day.

In case of infection With ankylostoma duodenale outside the endemic areas (occurs more easily) — at a dose of 12, 5 mg/kg per 1 dose.

Overdose:

Symptoms: no signs of serious intoxication.

There is no specific antidote.

Treatment: gastric lavage.

Special instruction:

The doctor should be informed about the existing liver diseases. When enterobiosis requires simultaneous treatment of all living together (infection is often asymptomatic). To prevent re-infection, it is necessary to strictly observe the rules of hygiene (wash your hands, cut and clean your nails, avoid combing the perineum area, change bed and underwear daily). After completion of treatment should be a control study of feces for the presence of helminth eggs.