Expiration date: 11/2026

dosage form

suppositories from white to white with Valium or a yellowish tint.

Composition

1 suppository contains ketoconazole - 400 mg suppository base (macrogol 1500 and macrogol 400) to obtain the suppository weight 2.4 g

pharmachologic effect

The active substance - ketoconazole, a derivative imidazoldioksolana. Has fungicidal effect and fungostaticheskoe against dermatophytes (Trichophyton spp., Epidermo-phyton floccosum, Microsporum spp.) And yeast (Pityrosporum spp., Candida spp. (Including Candida albicans). The mechanism of action is the inhibition of ergosterol biosynthesis and changes in the lipid composition of the membrane of fungi.

The drug is active against staphylococci and streptococci.

Mode of application

The drug is used vaginally, ie inserted into the vagina. To remove the suppository from the cell package, break off a single cell with a suppository for nips and separating the edges of the tape, pull for them in different directions. Suppository inserted into the vagina a pointed end, possibly deeper. For the prevention of fungal infections suppositories applied at a dose of 200 mg 1 time per day for 10 days. For the treatment of thrush - suppositories in the dose of 200 mg 2 times a day, or suppositories, 400 mg 1 time per day for 3 days. When genital fungal infections, acute and chronic vaginal candidiasis - suppositories in the dose of 200 mg 2 times a day, or suppositories, 400 mg 1 time per day for 5 days. You can combine the use of tablets (oral), and suppositories (vaginally).

Side effects

There are local and allergic reactions.

Local reactions: redness and irritation of the vaginal mucosa, vaginal itching; rarely - redness and pain in the penis from a sexual partner.

Allergic reactions: skin rash, urticaria.

Special conditions

During treatment should be regularly monitored picture peripheral blood, liver function and kidney.

Avoid contact with latex drugs (contraceptive diaphragms, condoms.

testimony

Treatment of acute and chronic recurrent vaginal mycosis.

Prevention of fungal infections of the vagina at a reduced resistance of the organism and during treatment with antibacterial agents and other drugs that violate the normal microflora of the vagina.

Contraindications

Hypersensitivity to the drug, pregnancy, lactation.

Carefully:

Children under 12 years of age (safety and efficacy not established).

Drug interactions

In an application with rifampicin and isoniazid reduced the concentration of ketoconazole in the plasma. At simultaneous application with cyclosporine, indirect anticoagulants and methylprednisolone ketoconazole may increase the concentration of the latter in the plasma. Ethanol and other hepatotoxic drugs increase the risk of hepatic parenchyma. Increasing the concentration of sulfonylurea derivatives and increase the risk of hypoglycemia. It weakens the effect of amphotericin B. It increases the concentration of digoxin in plasma, midazolam, and triazolam. Increases bio-availability of indinavir. It reduces a stimulating effect on the adrenal corticotropin. When combined with ter-fenadinom, astemizole, and cisapride increases the risk of severe ventricular tachycardia, including "Pirouette" type. It increases the risk of "breakthrough" bleeding when using a one-stage perroralnyh contraceptives with low hormones. Increases toxicity of phenytoin.