Sympatholytics called substances that reduce the amount of neurotransmitter released in the endings of the sympathetic nerves, and thereby inhibiting the transfer of adrenergic stimulation. Unlike blocker sympatholytics with postsynaptic adrenoceptors not interact. The main representatives of this group are reserpine, guanethidine, bretylium tosylate. Wide use of these drugs currently do not have. Reserpine included in the number of antihypertensive drugs combined.