Expiration date: 01/2025
DESCRIPTION
Melbimax-tablets for cats and kittens with nematodoses and cestodoses. In appearance, it is an elongated tablet with beveled edges and a transverse notch on one side. Tablets for kittens and young cats are covered with a pink shell.
STRUCTURE
Containing oxime and praziquantel as active ingredients of milbemycin, as well as auxiliary components. They are produced in the form of tablets for kittens and young cats with a content of 4 mg of milbemycin oxime and 10 mg of praziquantel in 1 tablet. In appearance, it is an elongated tablet with beveled edges and a transverse notch on one side. Tablets for kittens and young cats are covered with a pink shell. Pack 2 tablets in foil blisters, which are packed in cardboard boxes.
PHARMACOLOGICAL PROPERTIES
Milbemycin oxime and praziquantel exhibit synergistic effects and, in combination, have a wide spectrum of action on larval and sexually mature forms of nematodes and cestodes. Milbemycin oxime, which is part of the drug, belongs to the group of macrocyclic lactones released as a result of the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus. Milbemycin oxime is active against nematodes that parasitize the gastrointestinal tract of cats, as well as the larvae of the nematode Dirofilaria immitis. The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes to chlorine ions, which leads to overpolarization of the membranes of nerve and muscle tissue cells, paralysis and death of the parasite. The maximum concentration of milbemycin oxime in the blood plasma is reached after 2 hours. The compound is mainly excreted unchanged from the body, the half-life is about 13 hours after oral administration of the drug. Praziquantel is an acylated derivative of pyrazine-isoquinoline, has a pronounced effect against cestodes and nematodes. By increasing the permeability of the parasite's cell membranes to calcium ions, it causes membrane depolarization, muscle contraction, and the destruction of the tegument, which leads to the death of the parasite and promotes its excretion from the animal's body. The maximum concentration of praziquantel in the blood plasma is reached after 1 hour. From the body, the compound is excreted mainly in the form of inactive metabolites in the urine, the half-life is about 3 hours after oral administration of the drug. Milbemax belongs to the group of moderately dangerous compounds for warm-blooded animals, in the recommended doses it does not have a sensitizing, embryotoxic and teratogenic effect. It is well tolerated by cats of different breeds and ages. The drug is toxic to fish and other aquatic organisms.
INDICATIONS
It is prescribed for prophylactic and therapeutic purposes for deworming cats with nematodoses (toxocarosis, hookworm disease) and cestodoses (echinococcosis, dipylidiosis, teniosis).
DOSAGE AND METHOD OF ADMINISTRATION
Milbemax is given to cats orally once, individually in the morning feeding with a small amount of feed, or forcibly administered to the root of the tongue after taking food at a minimum therapeutic dose of 2 mg of milbemycin oxime and 5 mg of praziquantel per 1 kg of animal weight.
Kittens and young cats, weight Dosage
0.5-1 kg ½ tablet
1-2 kg 1 tablet
It is necessary to monitor the consumption of the drug. A preliminary starvation diet and the use of laxatives are not required. Milbemax can be used for kittens from 6 weeks of age. For pregnant cats, the drug is used in the last third of the pregnancy period, for lactating cats-2 to 3 weeks after lambing under the supervision of a veterinarian. Preventive deworming is recommended to be carried out quarterly, as well as before vaccination and mating in the above doses.
SIDE EFFECTS
In animals hypersensitive to the components of milbemax, allergic reactions are possible. With proper use and dosage, side effects are usually not observed. With an overdose, some cats may experience tremor, the symptoms of which spontaneously disappear within a day and do not require the use of medications.
CONTRAINDICATIONS
Increased individual sensitivity to the drug. It is forbidden to prescribe milbemax to kittens younger than 6 weeks of age, cats in the first two-thirds of the pregnancy period, as well as patients with infectious diseases and recovering animals. It is not recommended to use cats weighing less than 0.5 kg. Do not use in animals with impaired kidney and liver function.
SPECIAL INSTRUCTIONS
No special precautions are provided.
STORAGE AND SHELF LIFE
With a List B precaution. In a dry, dark and inaccessible place for children and animals at a temperature of 0 to 30 °C. Shelf life — 3 years. The shelf life after opening the blister is 6 months.
