Expiration date: 01/2025
Gentamicin sulfate is an aminoglycoside antibiotic with bactericidal action. In appearance, it is a colorless or slightly yellow transparent solution for injection.
STRUCTURE
The composition of the drug includes several antibiotics produced by Micromonospora purpurea and in 1 ml contains 40 mg of gentamicin sulfate and auxiliary components: sodium pyrosulfite, disodium salt of ethylenediamine tetraacetic acid and water for injection.
PHARMACOLOGICAL PROPERTIES
Gentamicin has a broad spectrum of antimicrobial action. It is active against most Gram-negative and Gram-positive microorganisms, including proteus, Escherichia, Salmonella and staphylococci. The antibiotic does not work on anaerobic bacteria, fungi, viruses and protozoa.
When administered intramuscularly, the drug penetrates well into many organs and tissues. The maximum concentration in the blood is reached 1 hour after administration. After a single injection, the therapeutic concentration of the antibiotic in the body is maintained for 8 to 12 hours after administration.
When used orally, the drug is practically not absorbed from the gastrointestinal tract and has its effect only in the intestine for 12 hours. With parenteral administration of gentamicin, the antibiotic is excreted unchanged from the body mainly in the urine, and with oral administration-with feces.
APPLICATION
Gentamicin solution is used intramuscularly or orally twice a day at intervals of 10-12 hours
SIDE EFFECTS
Ototoxic and nephrotoxic effects.
CONTRAINDICATIONS
Simultaneous or sequential use of gentamicin with other ototoxic and nephrotoxic drugs(streptomycin, kanamycin, neomycin) is not allowed.
It is not allowed to use the drug in severe renal impairment.
SPECIAL INSTRUCTIONS
Slaughter of animals for meat is allowed 21 days after the last use of the drug. Milk obtained from animals treated with gentamicin should not be used for food purposes during the treatment period and within 72 hours after discontinuation of the drug.
STORAGE
Store in the closed packaging of the manufacturer, in a dry place, protected from light and out of reach of children from plus 5°C to plus 25°C. Shelf life under storage conditions-2 years. Open vials with the drug can be stored for no more than 28 days.
PACKAGING
The drug is available packaged in 10ml bottles.
