Expiration date: 01/2025

Benzylpenicillin sodium salt is a drug for the treatment of diseases of bacterial etiology in farm animals, dogs and fur-bearing animals. Dosage form: powder for the preparation of a solution for injection. In appearance, the drug is a fine crystalline powder of white or slightly yellowish color.

STRUCTURE

The drug as an active substance contains benzylpenicillin sodium salt - not less than 1650 units/mg (in terms of dry matter).

PHARMACOLOGICAL PROPERTIES

Benzylpenicillin sodium salt for injection belongs to the antibacterial drugs of the penicillin group.

Benzylpenicillin sodium salt is a salt of benzylpenicillinic acid produced by Penicillium notatum, active against Gram-positive microorganisms (streptococci, staphylococci, pneumococci, enterococci, most anaerobes, actinomycetes, Clostridium, anthrax bacillus), some Gram-negative cocci (gonococci, meningococci), as well as spirochetes.

The antimicrobial action of Benzylpenicillin sodium salt is based on the suppression of the biosynthesis of the cell wall of the microorganism, which is based on a complex peptidoglycan. Penicillins inhibit the activity of enzymes involved in the synthesis of peptidoglycan, which stops the growth of microorganisms. At the same time, the enzymes that hydrolyze peptidoglycan are activated, and the covalent bonds of the cell wall are broken. Growing cells stop dividing, swell, and disintegrate.

After intramuscular administration of Benzylpenicillin, sodium salt is rapidly absorbed into the blood, distributed in the extracellular fluid, and penetrates into organs and tissues. The maximum concentration of the antibiotic in the blood is reached 30 minutes after administration and is maintained at the therapeutic level for 4-6 hours. It is excreted from the body, mainly in the urine; the remaining amount-with bile, milk.

Benzylpenicillin sodium salt for injection according to the degree of exposure to the body belongs to the 2nd hazard class according to GOST 12.1.007 (highly hazardous substances).

The use of benzylpenicillin sodium salt for injection in the early stages of pregnancy can increase the contractile activity of the uterus and increase the number of spontaneous abortions. Penicillins pass through the placenta. When penicillins were administered in doses 2-25 times (for different penicillins) higher than therapeutic ones, no fertility disorders or effects on reproductive function were found. Teratogenic, mutagenic, and embryotoxic properties were not detected when penicillins were administered to animals.

INDICATIONS

Benzylpenicillin sodium salt for injection is used for the treatment of anthrax, necrobacteriosis, pasteurellosis, pneumonia, mastitis, endometritis, wound infection, emphysematous carbuncle and streptococcal septicemia of large and small cattle; myt and catarrhal pneumonia of horses; streptococcosis and staphylococcosis of fur-bearing animals and dogs; erysipelas of pigs and other diseases, the pathogens of which are sensitive to benzylpenicillin.

APPLICATION

Before use, the drug is dissolved in 5-10 ml of water for injection or a sterile isotonic solution of sodium chloride, after piercing the bottle stopper with a needle.

The prepared solution is administered intramuscularly at intervals of 4-6 hours for 5-7 days.

If you accidentally miss the introduction of the next dose of the drug, it should be administered as soon as possible in the prescribed dosages and the scheme of application.

SPECIAL INSTRUCTIONS

Slaughter of animals for meat is allowed no earlier than 3 days after the last use of the drug. The meat of animals forcibly killed before the expiration of the specified period can be used for feeding carnivores.

Milk obtained from animals during the treatment period and within 24 hours after the last injection of Benzylpenicillin sodium salt is forbidden to be used for food purposes. Such milk can be used after heat treatment for feeding animals.

CONTRAINDICATIONS

A contraindication for the use of Benzylpenicillin sodium salt for injection is an individual hypersensitivity of the animal to antibiotics of the penicillin group.

The simultaneous use of Benzylpenicillin sodium salt for injection with other antibiotics (aminoglycosides, tetracyclines, levomycetin), epinephrine, eufilin, ascorbic acid, B vitamins and non-steroidal anti-inflammatory drugs is prohibited.

OVERDOSE

With an overdose of the drug, the animal may experience neurotoxic symptoms (nausea, vomiting, increased reflex excitability). In these cases, the drug is canceled and the animal is prescribed specific and symptomatic therapy.

SIDE EFFECTS

When using Benzylpenicillin sodium salt for injection in accordance with this instruction, side effects and complications are usually not observed. With increased individual sensitivity of the animal to benzylpenicillin sodium salt and the appearance of allergic reactions (urticaria, diarrhea, angioedema, anaphylactic shock), the use of the drug is discontinued and desensitizing therapy is performed.

SAFETY PRECAUTIONS

When working with Benzylpenicillin sodium salt for injection, the general rules of personal hygiene and safety provided for when working with medicines should be observed. People with hypersensitivity to the components of the drug should avoid direct contact with Benzylpenicillin sodium salt for injection.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes of the eye, they should be washed with plenty of water. In case of allergic reactions or accidental ingestion of the drug in the human body, you should immediately contact a medical institution (you should have the instructions for using the drug and the label).

SHELF LIFE AND STORAGE

Benzylpenicillin sodium salt for injection is stored in the closed packaging of the manufacturer, separately from food and feed, in a place protected from direct sunlight at a temperature of 5°C to 25°C. The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of production.

PACKAGING

The drug is produced packaged in 1 000 000 units. the active substance in glass bottles with a capacity of 10 ml.