Expiration date: 10/2025
Structure and Composition
Clotrimazole vaginal tablets Active ingredient - clotrimazole 100, 200 or 500 mg
Excipients: lactose, corn starch, Aerosil, soda, tartaric acid, magnesium stearate,
1, 3, 6 pcs. complete with applicator in a cardboard bundle.
Clotrimazole ointment 1%: 1 g of ointment contains 10 mg clotrimazole,
in 20 g tubes
1% clotrimazole cream 1 g contains 10 mg clotrimazole,
Other ingredients: benzyl alcohol, cetostearyl alcohol, evtanol the G, Polysorbate 60, Span 60, olbrot synthetic, purified water,
in the box on 20 and '30
Clotrimazole topical solution 1% 1 ml contains 10 mg of clotrimazole,
Excipients: isopropyl miristinat, anhydrous ethanol,
15 ml vial with a dropper.
Pharmachologic effect:
Clotrimazole is an imidazole derivative. Broad antifungal spectrum. The effect of the drug is associated with impaired synthesis of ergosterol, a component of fungal cell membranes, causing changes in its structure and properties leads to cell lysis.
By clotrimazole sensitive dermatophytes, yeasts (the genus Candida, Torulopsis glabrata, the genus Rhodotorula), molds, as well as the causative agent of Pityriasis versicolor (pityriasis versicolor) and pathogen zritrazmy.
Furthermore, providing antimicrobial activity against Gram-positive (staphylococci, and streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis, Malasseria furfur, Corinebacterium minussimum.
Indications
vaginal Tablets
Genital infections caused by the yeast Candida species and / or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis), genital superinfection, caused by bacteria sensitive to clotrimazole, as a prophylactic measure to gynecological procedures.
Cream
Ringworm, pityriasis versicolor, erythrasma, vulvovaginal candidiasis and balanitis.
Ointment
Fungal diseases of the skin, mycosis skin folds, feet,
pityriasis versicolor, erythrasma superficial candidiasis, caused by dermatophytes, yeasts (including Candida genus), molds and other fungi and pathogens susceptible to clotrimazole,
mycoses complicated by secondary pyoderma.
Solution for external application
Fungal skin and mucous membranes. Mycoses of feet / hands, smooth skin of the trunk, limbs, folds, the beard, the mustache, the scalp caused by dermatophytes. Pityriasis versicolor, zritrazma, skin candidiasis, genital mucosa, paronychia.
Dosing and Administration
Vaginal tablets
For the treatment of vaginal infections appoint 1 tablet (100-500 mg), 1 per day (night).
Vaginal tablets introduced as deeply as possible into the vagina.
The duration of the treatment - 6 days.
If necessary, treatment can be repeated.
Ointment, cream
Outwardly. Apply a thin layer of 2-3 times a day on precleaned (with soap at a neutral pH) and dry skin lesions and gently rubbed. The duration of treatment depends on the severity of the disease, localization of lesions and the effectiveness of therapy.
tinea treatment is carried out at least 4 weeks tinea versicolor -1-3 weeks.
When fungal foot skin diseases treatment is recommended to continue for a further 2 weeks at least after elimination of symptoms.
Solution for external application
A few drops of the solution should be easy to rub in the changed areas of the skin 2-3 times / day. After elimination of the acute symptoms of the disease treatment should be continued for at least 4 weeks.
When tinea pedis drug should be used even for 2 weeks after the elimination of all symptoms of the disease in order to prevent recurrence of the disease.
It is recommended to use the solution after each washing of feet.
The drug should not be used with occlusive dressing.
Side effect
Spasms of the lower gastrointestinal tract, generalized erythema, rash.
Local reactions: redness, burning sensation and tingling.
Contraindications
Hypersensitivity to clotrimazole, I trimester of pregnancy.
special instructions
To prevent the spread of urogenital infection should be simultaneous treatment of sexual partners. Trichomoniasis for a more successful treatment with clotrimazole jointly be administered other drugs having systemic effect (e.g., metronidazole orally).
Vaginal tablets are not recommended for use during menstruation.
In the event of an unintended route of administration (oral), the following symptoms - anorexia, nausea, vomiting, gastralgia, abnormal liver function, rarely somnolence, hallucinations, pollakiuria, skin allergic reactions. In ztih situations it is necessary to take activated charcoal and consult a doctor.
When razvivitii allergic reactions or irritation, treatment should be stopped and choose another therapy.
When tinea pedis is recommended to use the solution after each washing of feet.
Not recommended applying the preparation on the skin around the eyes.
If after 4 weeks from the start of treatment were observed clinical improvement, it is necessary to confirm the diagnosis microbiologically and rule out other causes of the disease.
Drug interactions
It reduces the effect of polyene antibiotics (amphotericin B, nystatin, natamycin, etc.). Propyl ester of para-hydroxybenzoic acid in high concentrations enhances the antifungal effect of clotrimazole, dexamethasone - decreases.
While the use of clotrimazole Nystatin activity may decrease.
Storage conditions
In a dry, dark place at a temperature of 15 ° C-25 ° C. Keep out of the reach of children.
Shelf life - 3 years.
