Expiration date: 05/2025
Clinico-pharmacological group: An antifungal drug for external use
Release form, composition and packaging.
1 ml contains terbinafine hydrochloride 10 mg
Spray for external use 1% in the form of transparent, colorless or pale yellow liquid with a characteristic odor of ethyl alcohol.
Excipients: rectified ethanol, propylene glycol, poloxamer (proxanol 268), purified water.
15 or 30g - polypropylene bottles (1) with a metering pump, a nozzle and protective cap - packs of cardboard.
Pharmacological action
Antifungal agent, allilamin. It has a broad spectrum of antifungal activity.Active against dermatophytes: Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum, Microsporum canis, Epidermophyton floccosum. In low concentrations has a fungicidal effect on dermatophytes, mould fungi (including Aspergillus, Cladosporium, Scopulariopsis brevicaulis) and certain dimorphic fungi. In yeast fungi of the genus Candida (mainly Candida albicans) and filamentous forms, depending on the species, the drug has fungicidal or fungistatic.Termicon violates the early stage of the biosynthesis of the main components of the cell membrane of the fungus ergosterol by inhibiting enzyme squalene epoxidase. This leads to a deficiency of ergosterol and to an intracellular accumulation of squalene, which causes cell death of the fungus. The action of terbinafine by inhibiting the enzyme squalene epoxidase, located on the cell membrane of the fungus.
Pharmacokinetics
When applied topically spray is absorbed less than 5% of the dose, thus the systemic effect of the drug is minimal.
Dosage
The duration of treatment and dosage regimen is determined individually and depends on the location and severity of the disease.Externally the drug is prescribed to adults 1-2 times/day depending on testimony. Before applying the medication should be clean and dry affected areas. The drug is sprayed on the affected skin and surrounding area in an amount sufficient for wetting, and, furthermore, applied to the surrounding areas of intact skin
| Testimony | The duration of treatment | The multiplicity of the drug |
| Ringworm of trunk, legs | 1 week | 1 time a day |
| Ringworm of the feet | 1 week | 1 time a day |
| Pityriasis versicolor | 1 week | 2 times a day |
The dosing regimen for elderly patients is the same as for younger adults.Peredozirovka cases of overdose of Termicon in the form of a spray for external use was not reported. If you accidentally taking the drug inside, get the same side effects as the admission of Termicon tablets (nausea, vomiting, pain in the lower abdomen and epigastric area, dizziness). You should also consider the content of ethanol in the formulation.Treatment: activated charcoal, if necessary - symptomatic supportive therapy.
Drug interactions
Currently, drug interaction of Termicon unknown.
Pregnancy and lactation
Termicon should be applied under strict indications and in the case that the expected benefit to the mother outweighs the potential risk to the fetus.In the case of a nursing mother Termicon absorbed through the skin a small amount of active substance, therefore, adverse effects on the baby are unlikely.In experimental studies teratogenic effects of terbinafine have not been identified. So far not reported any defects with the use of terbinafine.
Side effects
Local reactions: possible redness, itching or burning sensation.Allergic reactions are possible.
Terms and conditions storage
The drug should be stored out of reach of children at temperature not exceeding 30°C, do not freeze. Shelf life - 2 years.
Testimony
— prevention and treatment of fungal skin infections, including athlete's foot, Jock itch (tinea cruris), fungal defeat smooth skin (tinea corporis), caused by such dermatophytes as Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum, Microsporum canis and Epidermophyton floccosum,— pityriasis versicolor caused by Pityrosporum orbiculare (Malassezia furfur).
Contraindications
— hypersensitivity to the drug.With caution should use the drug in patients with renal and/lipectomy failure, alcoholism, oppression kostnomozgovy blood, tumors, metabolic diseases, occlusal diseases of blood vessels of limbs, in children under the age of 12.
Special instructions
Note that the irregular use or premature termination of treatment increases the risk of relapse.If after 1 week of treatment with Termicon not marked improve condition, you have to re-determine the causative agent and its sensitivity to the drug.When drug treatment should follow the General rules of hygiene to prevent reinfection through underwear and shoes. In the process (through 2 ned.) and at the end of the treatment, it is necessary to produce the antifungal treatment of footwear, socks and stockings.Termicon intended for external use only. Avoid falling drug in the eye because it can cause irritation. In case of contact with eyes, rinse with running water, and in the case of persistent irritation, the patient should consult a doctor. In case of accidental contact of the drug in the respiratory tract in case of any symptoms, especially when saving, the patient should also consult with your doctor. Use caution when applying Termicon on damaged areas of skin, because alcohol is part of it, may cause irritation.In developing allergic reactions the drug should be discontinued.Use in pediatric use of Termicon in spray form in children under the age of 12 lithographien.Effects on ability to drive vehicles and management MechanismInternational not affect the ability to drive vehicles and perform work, require high concentration and speed of psychomotor reactions.Used in the dysfunction of occpational with renal insufficiency inside administered 125 mg 1 times/day.With caution should designate product externally with renal nedostatochnosti in violation of the functions of pecheni caution should designate product inside and externally for liver failure.
