Expiration date: 01/2025

Composition and form of release:

Vitaprost:

Suppositories for rectal use 1 supp.

substance "Vitaprost" (prostate extract) 0, 05 g

(in terms of 20% water-soluble peptides content)

excipients: solid fat (vitepsol) - sufficient amount to obtain a suppository weighing 1, 25 g

in a contour cell package of 5 PCs. in a pack of cardboard 1 or 2 packages.

Tablets coated with a shell that is soluble in the intestine 1 table.

substance "Vitaprost" (prostate extract) 0, 1 g

excipients: to obtain a core weight of 0, 25 g-sugar (sucrose) milk sugar (lactose) calcium stearate (calcium stearic acid, 1-water) crospovidone (polyplasdon XL-10, collidone) MCC

shell composition: no more than 10% of the average weight of the core-acrylic-is (copolymer of methacrylic acid with ethylacrylate 1:1 titanium talc triethylcitrate silicon oxide colloidal anhydrous sodium bicarbonate sodium lauryl sulfate Indigo Carmine)

in a contour cell package of 10 PCs. in a pack of cardboard 1 or 2 packages.

Vitaprost Forte:

Suppositories for rectal use 1 supp.

substance "Vitaprost" (prostate extract) 0, 1 g

excipients: vitepsol-sufficient amount to obtain a suppository weighing 1, 25 g

in a contour cell package of 5 PCs. in a pack of cardboard 1 or 2 packages.

Vitaprost plus:

Suppositories for rectal use 1 supp.

substance "Vitaprost" * (prostate extract) 100 mg

(in terms of water-soluble peptides-100 mg)

lomefloxacin hydrochloride (lomefloxacin) 400 mg

excipients: base for suppositories: solid fat (vitepsol) - sufficient amount to obtain a suppository weighing 2, 25 g

* Vitaprost substance (prostate extract) is an extract from the prostate tissue of bulls and bulls that have reached puberty

in a contour cell package of 5 PCs. in a pack of cardboard 1 or 2 packages.

Description of the dosage form:

Vitaprost:

Suppositories are white to white with a yellowish or grayish-brownish tinge of color, torpedo-shaped.

Tablets covered with an intestinal-soluble shell, from blue to light blue, round, biconvex, the presence of inclusions is possible.

Vitaprost Forte:

Suppositories from white with yellowish to cream with a grayish tinge of color, torpedo-shaped.

Vitaprost plus:

Suppositories from white or almost white to light cream with a grayish tinge of color, torpedo-shaped.

Pharmacological action:

Vitaprost, Vitaprost Forte:

Anti-inflammatory, antiaggregational, organotropic effect on the prostate.

Vitaprost plus:

Antibacterial, anti-inflammatory, antiaggregational, organotropic effect on the prostate.

Description of pharmacological action:

Vitaprost, Vitaprost Forte:

Reduces the degree of edema, leukocyte infiltration of the prostate, normalizes the secretory function of epithelial cells, increases the number of lecithin grains in the secret of acinuses, stimulates the muscle tone of the bladder. Improves microcirculation in the prostate by reducing thrombosis, antiplatelet activity, prevents the development of venous thrombosis in the prostate.

Based on clinical studies, it has been proven that Vitaprost and Vitaprost Forte reduce the volume of the prostate gland. Drugs reduce the severity of obstructive and irritative symptoms in benign prostatic hyperplasia, which is expressed in an increase in the maximum and average volumetric flow rates of urine and a decrease in the volume of residual urine.

Data from clinical studies have shown that the use of the drug Vitaprost tablets reduces the likelihood of developing exacerbations of chronic abacterial prostatitis, does not cause changes in the indicators of clinical and biochemical blood analysis, General urine analysis. The effectiveness of the drug Vitaprost tablets for the prevention of exacerbations of chronic abacterial prostatitis of doctors-researchers is 97, 5%.

Normalizes the parameters of the prostate and ejaculate. Reduces pain and discomfort caused by prostatitis, eliminates dysuric phenomena, improves copulatory function.

Vitaprost plus:

The combined drug has antimicrobial and anti-inflammatory properties.

Lomefloxacin is a broad-spectrum bactericidal agent from the group of fluoroquinolones. It affects the bacterial enzyme DNA-gyrase, which provides superspiralization, forms a complex with its tetramer (subunits of gyrase A2B2) and disrupts the transcription and replication of DNA, leading to the death of the microbial cell. Highly active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter diversus, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella morganii, Haemophilus influenzae et parainfluenzae, Legionella pneumophila, Pseudomonas aeruginosa. Moderately sensitive to the drug — Staphylococcus aureus, Staphylococcus epidermidis, Serratia liquefaciens, Serratia marcescens, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans. Resistant to the drug —Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis, and anaerobic bacteria. Most microorganisms are affected in low concentrations (the concentration required to suppress the growth of 90% of strains, usually no more than 1 mcg/ml). Resistance develops rarely.

Substance "Vitaprost" (prostate extract) reduces the degree of edema, leukocyte infiltration of the prostate, normalizes the secretory function of epithelial cells, increases the number of lecithin grains in the secret of acinuses, stimulates the muscle tone of the bladder. Reduces thrombus formation, has antiplatelet activity, prevents the development of thrombosis venules in the prostate gland. Normalizes the parameters of the prostate and ejaculate. Reduces pain and discomfort, improves copulatory function.

Indications:

Vitaprost (rectal suppositories):

• chronic prostatitis
• conditions before and after prostate surgery.

Vitaprost (tablets):

• chronic abacterial prostatitis
• prevention of exacerbations of chronic abacterial prostatitis
• benign prostatic hyperplasia
• conditions before and after prostate surgery.

Vitaprost Forte:

• chronic prostatitis
• BPH
• conditions before and after prostate surgery
• treatment of urgent (imperative) urinary incontinence, urgent (imperative) urge to urinate and frequent urination in uncomplicated forms of bladder hyperactivity in women in the menopausal and post-menopausal periods.

Vitaprost plus:

• acute and chronic bacterial prostatitis caused by sensitive microorganisms, including in combination with other inflammatory diseases of the genitourinary tract
• conditions before and after prostate surgery.

Contraindications:

Vitaprost, Vitaprost Forte:

• hypersensitivity to the components of the drug.

Vitaprost plus:

• hypersensitivity to the components of the drug
• age up to 18 years (the period of formation and growth of the skeleton).

With caution:

• cerebral atherosclerosis
• epilepsy and other CNS diseases with epileptic syndrome.

Side effect:

Vitaprost, Vitaprost Forte:

• Allergic reactions (extremely rare).

Vitaprost plus:

Side effects of the drug are associated with the presence of the antibiotic lomefloxacin in its composition.

Allergic reactions: skin itching, urticaria, photosensitization, malignant exudative erythema (Stevens-Johnson syndrome).

From the nervous system: asthenia, dizziness, nervousness, anxiety.

From the digestive system: pseudomembranous enterocolitis, dysbacteriosis, increased activity of "liver" transaminases.

From the hematopoietic system and hemostasis: bleeding from the gastrointestinal tract, thrombocytopenia, increased fibrinolysis, lymphadenopathy.

From the cardiovascular system: decreased blood PRESSURE, arrhythmia, myocardiopathy.

The substance "Vitaprost" (prostate extract) rarely causes allergic reactions.

Drug interaction:

Vitaprost plus:

Increases the activity of oral anticoagulants and increases the toxicity of NSAIDs.

Drugs that block the tubular secretion slow down the excretion of the drug.

There is no cross-resistance with penicillins, cephalosporins, aminoglycosides, co-trimoxazole, metronidazole.

Dosage and administration:

Vitaprost Forte:

Rectally, 1 supp. 1 time a day after spontaneous bowel movement or cleansing enema. After administration of the drug, it is desirable to stay in bed for 30-40 minutes.

The duration of treatment is determined by the attending physician. The minimum duration of treatment with Vitaprost Forte for BPH is 15 days, for chronic prostatitis-10 days.

Vitaprost:

Pills. Inside, 1 table. 2 times a day. Duration of treatment: for BPH-at least 30 days for chronic prostatitis-at least 10 days.

To prevent exacerbations of chronic prostatitis - 1 table. 2 times a day for at least 30 days — 1-2 times a year.

Rectal suppositories. Rectally, after spontaneous bowel emptying or cleansing enema-1 supp. Once a day (after administration, it is recommended to stay in bed for 30-40 minutes). The course duration is at least 10 days.

Vitaprost plus:

Rectally, 1 supp. 1 time a day after an enema or self-emptying of the intestines. Before using the suppositories should be removed from the contour cell packaging. After administration of the drug, it is desirable to stay in bed for 30-40 minutes. The course of treatment continues until the pathogen disappears in the secret of the prostate and is from 10 to 30 days (the duration of treatment is determined by the doctor individually for each patient).

Special instruction:

Vitaprost, tablets coated with a shell that is soluble in the intestine

Treatment of chronic prostatitis and conditions before and after prostate surgery should be comprehensive, involving the use of various groups of medications and non-drug treatment methods.

Vitaprost plus:

With cirrhosis of the liver, no correction of the dosage regimen is required (provided that the kidneys function normally).

During treatment, long-term exposure to sunlight and the use of artificial UV lighting should be avoided. At the first signs of photosensitization (increased skin sensitivity, burn, hyperemia, edema, blisters, rash, itching, dermatitis), hypersensitivity, manifestations of neurotoxicity (agitation, convulsions, tremor, photophobia, confusion, toxic psychosis, hallucinations), therapy should be discontinued.

During treatment, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.