Expiration date: 08/2025
Testimony
— sleep disorder, including due to a violation of the rhythm of "sleep-Wake", such as DS (a sharp change of time zones).
Contraindications
— hypersensitivity to the drug; — autoimmune diseases; — liver failure; — severe renal insufficiency; — children up to age 18 years.
Side effects
Infectious and parasitic diseases: rare - herpes zoster. The blood and lymphatic system: rarely - leukopenia, thrombocytopenia. The immune system: frequency unknown - hypersensitivity reactions. From the metabolism and nutrition: rare hypertriglyceridemia, hypokalemia. hyponatremia. Psychiatric disorders: infrequent - irritability, neuronet, anxiety, insomnia, unusual dreams, nightmares, anxiety; rarely mood swings, aggression, agitation, crying, stress symptoms, disorientation, early morning awakening, increased libido, lowered mood, depression. From the nervous system: infrequently - migraine, headache, lethargy, psychomotor hyperactivity, dizziness, drowsiness; rarely - syncope, impaired memory, impaired concentration, dream-like state, the syndrome of "restless" legs, poor sleep quality. paresthesia. From the body of the vision: rarely - decreased visual acuity, blurred vision, increased lacrimation. On the part of the organ of hearing and labyrinth disorders: rarely, vertigo, positional vertigo. Heart: rarely - angina pectoris, palpitations. From vessels: infrequently - arterial hypertension; rare - "tides". Gastrointestinal: infrequent - abdominal pain, abdominal pain in the upper abdomen, dyspepsia, ulcerative stomatitis, dry mouth, nausea; rarely - gastroesophageal reflux disease, gastrointestinal disturbance or disorder, the formation of bubbles on the mucous membrane of the oral cavity. ulcerative glossitis, vomiting, abnormal bowel sounds, flatulence, hypersecretion of saliva, bad breath, abdominal discomfort, indigestion, gastritis. The liver and biliary tract: rarely - hyperbilirubinemia. The skin and subcutaneous tissue: often - dermatitis, night sweats, itching, and generalized itching. rash, dry skin; rarely eczema, erythema, hand dermatitis, psoriasis, generalized rash, itchy rash, loss of nails; frequency is unknown - angioedema, swelling of the mouth, swelling of the tongue. From the musculoskeletal and connective tissue: rare - pain in the extremities; rare - arthritis, muscle spasm, pain in the neck. night cramps. The part of the kidney and urinary tract disorders: rare - glycosuria, proteinuria; rarely - polyuria, hematuria, nocturia. From the genital organs and mammary glands: rarely - menopausal symptoms; rarely - priapism, prostatitis; frequency is unknown - galactorrhea. General disorders injection site: often - asthenia, chest pain; rarely - fatigue, pain, thirst. Laboratory and instrumental data: rare - abnormalities of laboratory parameters of liver function, increased body mass index; rarely - increased activity of "liver" transaminases, abnormal electrolyte content in the blood, abnormalities of laboratory tests. If any of the instructions adverse reactions worsen, or You notice other adverse reactions not mentioned in the instructions, inform your doctor.
Method of application and dosage
Inside, squeezed enough water. 3-6 mg/day one hour before bedtime for 4-7 days. When DS (rapid change in time zones) and 6 mg 1 hour before bedtime. then 3 mg within the first three days. Renal insufficiency the Effect of different degrees of renal insufficiency on melatonin pharmacokinetics has not been studied, therefore, melatonin should be used with caution in such patients. Patients with severe renal insufficiency the use of the drug is not recommended. Hepatic insufficiency there is No experience with the use of melatonin in patients with impaired liver function. Published data indicate a marked increase in the concentration of endogenous melatonin during daylight hours as a result of reduced clearance in these patients. Therefore, melatonin is not recommended in patients with impaired liver function. Elderly patients it is Known that the melatonin metabolism slows down with age, however, due to the high interindividual variability of pharmacokinetic parameters, even within groups with the same gender, it is difficult to give recommendations on the correct dose for elderly patients.
