Expiration date: 06/2025
Structure and Composition:
Tablets. One tablet contsins: thioridazine hydrochloride 10 mg
Excipients: corn starch colloidal silicon dvuoksid (Aerosil) lactose gelatin stearic acid, talc, sucrose, acacia dye cochineal red
in blisters of 30 pieces. 2 In the paper cartons packaging.
Tablets. One tablet contsins: thioridazine hydrochloride 25 mg
Other ingredients: sucrose, potato starch, gelatin, magnesium stearate, talc, gum arabic, quinoline yellow dye
in blisters of 20 pieces. in a stack of cardboard 3 packaging.
Pharmachologic effect:
It inhibits adrenergic and dopaminergic transmission at stem reticular formation of (predominantly) and cerebral cortex. It has antipsychotic (observed after 10-14 days of admission) and a weak antidepressant action. Blocks of H1-antihistamines and peripheral m-cholinergic receptors. It provides the most pronounced antihistamine and anticholinergic effects of all drugs from the group of neuroleptics.
Indications:
Schizophrenia, including paranoid, schizoaffective psychosis disorder, including involutional psychosomatic disorders depression, accompanied by a sense of fear of withdrawal syndrome in chronic alcoholism, pruritus (severe, painful) on skin diseases, behavioral disorders (increased psychomotor activity) in children.
Contraindications:
Hypersensitivity (including phenothiazine derivatives), depression (severe condition), coma, pheochromocytoma, porphyria, hematopoiesis failure, I trimester of pregnancy and last week, children up to 4 years.
Application of pregnancy and breastfeeding:
It contraindicated in I trimester and in the last week of pregnancy. In other periods possible if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.
Side effect:
From the nervous system and sensory organs: Parkinson's syndrome, dyskinesia, akathisia, somnolence, lethargy, irritability, depression, delirium, seizures, disturbance of thermoregulation.
Cardio-vascular system and blood (blood, hemostasis): tachycardia, orthostatic hypotension, agranulocytosis, leukopenia, eosinophilia, pancytopenia, thrombocytopenic purpura.
From the digestive tract: constipation, cholestatic jaundice.
For the skin: allergic reactions, discoid lupus erythematosus, photosensitivity.
Other: hyper- or hypoglycemia, gynecomastia, menstrual disorders, decreased libido.
Drug Interactions:
It enhances the effect of hypnotics, analgesics, antihypertensives, drugs and alcohol, anticholinergic activity of amitriptyline and antihistamines, hepatotoxic effects of antidiabetic agents, reduces the effect of levodopa, amphetamine, the hypotensive effect of guanethidine.
Dosage and administration:
Inside. Dosage and individual (depending on the indications and therapeutic response).
In psychoses: adults usually - 150-400 mg / day in 3-4 hours on an outpatient basis, in a hospital - 250-800 mg / day. Treatment is usually started with a low dosage of 25-75 mg / day, gradually increasing to their optimal therapeutic dose is achieved within 7 days (antipsychotic effect is observed after 10-14 days). The course of treatment is several weeks. Maintenance daily dose - 75-200 mg once daily at bedtime. Older people usually use the lowest dose - 30-100 mg / day. The drug should be withdrawn gradually.
In light of mental and emotional disorders: therapeutic dose - 50-200 mg / day. Treatment should start with a low dose and gradually increase to its optimal therapeutic dose.
In psychosomatic disorders - 10-75 mg / day.
To suppress the strong itch: the dose set individually, and it should not exceed 200 mg.
Children from 4 to 7 years - 10-20 mg / day in 2-3 doses per day from 8 to 14 years - 20-30 mg / day in 3 divided doses per day from 15 to 18 years - 30-50 mg / day 2-3 hours per day.
Precautionary measures:
To use caution in hypertrophy of the prostate with the difficulty urinating, angle-closure glaucoma, myasthenia gravis, Parkinson's disease, diseases of the cardiovascular system, ulcer disease, renal and / or hepatic insufficiency. Prolonged treatment is necessary to control blood picture. Should not be used during the drivers of vehicles and people skills relate to the high concentration of attention. During treatment excludes alcohol. Cancel the drug should be gradually.
