Expiration date: 02/2025
The composition and form of issue:
Powder lyophilized for solution preparation for oral administration and external application 1 vial contains:
a synthetic peptide consisting of 14 amino acid residues: Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu with a molecular weight of 1818 Dalton 1, 2 or 10 mg
in a bottle in the stack of cardboard 1, 3 or 30 vials or vial with the solvent in the vial and the syringe in the paper cartons 1 a bottle or vial with solvent (water for injection) in vials in cartons of 1 vial.
Description pharmaceutical form:
Sterile lyophilized amorphous white powder, easily soluble in water, physiological solution.
Feature:
A synthetic Oligopeptide consisting of 14 amino acid residues.
Pharmacological action:
Mechanism of action: triggers the production of alpha - and beta-interferons, mobilizes and activates macrophages, limits the production of proinflammatory cytokines (interleukins 1, 6, 8 and tumor necrosis factor), stimulates the production of antibodies to various antigens of an infectious nature, inhibits the replication of hepatitis virus C, herpes simplex 1 and 2 type, entsefalomiokardita, HIV, increases the resistance against infections caused by viruses, bacteria and fungi.
Patients infected with HIV, reduces the concentration of HIV in blood cells and plasma simultaneously activates the immune reactions specific to HIV. Most HIV patients, treatment leads to the following positive changes: increased content of CD4+ T and NK cells, increases functional activity of neutrophils and CD8+ T-cells, which are the key elements in protection against bacteria, viruses and fungi increases the production of antibodies specific to HIV antigens and to antigens of the causative agents of opportunistic infections relevant to the patient.
Pharmacokinetics:
Not been studied, in connection with a peptide nature of the drug.
Clinical pharmacology:
Used in the treatment of various diseases where there is a need to strengthen (restore) the immune response, speed up recovery, increase efficiency of treatment of acute or chronic infection, to prevent the recurrence of a chronic infection, to achieve healing of non-healing ulcers or wounds.
The clinical effect of treatment is to prevent recurrences of opportunistic infections within 3-6 months.
Short course topical application (three irrigation) allows to treat recurrent infections of mucous membranes and skin caused by fungi Candida.
Within 1-2 days upon application Gepon significantly reduced signs of inflammation, particularly the redness and swelling, and a feeling of soreness, burning, itching in the area of the inflamed mucous membranes and skin. The use of the drug is dryness of mucous membranes.
The efficiency of using Gepon with frequently recurrent respiratory infections chronic polyponic chronic rhinosinusitis pharyngitis acute respiratory diseases with symptoms of stenosing laryngotracheobronchitis dysbacteriosis of the intestine acute intestinal infections gastric ulcer and duodenal ulcer, other ulcer and erosive processes in the mucous membranes of acute and chronic viral hepatitis herpetic, chlamydial, Mycoplasma and other infections, dermatitis of various aetiology trophic ulcers in varicose veins, diabetes or as a result of radiation damage.
Indications:
Correction weakened immunity in immunodeficiency treatment of HIV infection improve the immune protection against infections, treatment and prophylaxis of opportunistic infections caused by bacteria, viruses or fungi the treatment of infections of the mucous membranes and skin caused by fungi Candida, prevention of candidiasis of mucous membranes and skin during antibiotic treatment reduction of inflammatory changes (redness, itching, swelling, burning, pain), mucous membranes and skin, and dry mucous membranes.
Contraindications:
Hypersensitivity to the drug children up to age 12 years.
Application of pregnancy and breast-feeding:
There is no data on drug effects on pregnant women. As in the case of other drugs, should not be used during pregnancy unless the benefits the patient, does not exceed the potential risk to the fetus. Not recommended for lactating mothers.
Side effects:
Not detected.
Drug interactions:
Not described.
Method of application and dose:
Inside, locally.
Adults and children 12 years and older recommended 10 mg orally 1 time a day, or 1-2 mg in the form of 0,02–0,04% solution for the local treatment of mucous and skin — 1 time per day.
Treatment of opportunistic infections in HIV infection or other immunodeficiency: treatment with daily intake of 10 mg orally for 1-3 months.
Treatment and prevention of candidiasis of mucous membranes and skin: local application by irrigation of the affected areas of the mucous membranes and skin, rate — 3 irrigation at intervals of 1-3 days. When vulvovaginitis, cervicitis, urethritis in women applying irrigation 0,02–0,04% solution of the mucosa of the vulva, vagina, cervix and lotions the affected areas of the skin adjacent to the entrance to the vagina. If urethritis balanoposthitis and men used instillation of 0.02–0.04% solution in the urethra and lotions on the affected skin. Treatment of mucous membranes and the skin repeated every 1 -3 days.
For the prevention of candidiasis of mucous membranes and skin as possible complications of antibiotic therapy are recommended irrigation (lotion) 0,02–0,04% solution during the course of antibiotic treatment.
To reduce the intensity of inflammation of the mucous membranes should be irrigated 0,02–0,04% solution, and the inflamed skin applying moistened in the same solution gauze.
