Expiration date: 06/2025

Form of issue, composition and packaging

Capsules vaginal translucent, gelatinous, size "0", the contents of capsules-powder light yellow with a brownish tinge.

1 capsule contains:

the freeze-dried culture of Lactobacillus i Lactobacillus rhamnosus Doderleini 341 mg*,

that corresponds to the content of viable lactic acid bacteria not less than 1×108KOE

Excipients: lactose monohydrate-5.59 mg, magnesium stearate-3.41 mg. * Excipients added to lyophilization: potato starch (~41% by weight of lyophilizate), lactose monohydrate (~20.6% by weight of lyophilizate), sodium glutamate (~4.5% by weight of lyophilizate), sodium thiosulfate (~26.8% by weight of lyophilizate).

The composition of the capsule shell: gelatin-98 mg. 14-bottles of colorless glass (1) - packs cardboard.

Clinical and pharmacological group: a drug that regulates the balance of vaginal microflora

Pharmacological action

Eubiotic for intravaginal use.Lactobacillus I-gram-positive rod-shaped anaerobic non-sporulating bacteria. Lactobacillus I-normal bonded flora of the oral cavity, intestine, vulva and vagina. Lactobacillus I, along with other types of Lactobacillus (including L. acidophilus, L. fermentum, L. cellobiosum), are represented in the normal flora of the vulva and vagina of women.Colonization of the vagina living sticks Lactobacillus rhamnosus i Doderleini creates similar physiological environment of the vagina. The strain Lactobacillus I rhamnosus Doderleini in the composition of the drug Lactoginal has antagonistic activity against a wide range of pathogenic and conditionally pathogenic bacteria (including Staphylococcus spp., Proteus spp., enteropathogenic Escherichia coli), improves local metabolism and promotes the restoration of natural local immunity.With the introduction of the capsule Lactinal vagina, the gelatin capsule dissolves to release a freeze-dried culture of live lactic acid bacteria.It was shown In vitro, that Lactobacillus I rhamnosus Doderleini within a few hours after administration lead to the necessary reduction of pH, contributing to the restoration of the natural microflora of the vagina.

Pharmacokinetics

Data on pharmacokinetics of the drug Lactoginal not provided.

Indications

• restoration of normal vaginal microflora after antibacterial therapy of bacterial vaginosis, - in preparation for planned gynecological operations, — in prenatal preparation for planned gynecological operations, — in prenatal preparation of pregnant women at risk for bacterial vaginosis.
  

Dosage regimen

Method of application - intravaginal.For restoration of normal vaginal microflora after antibacterial therapy of bacterial vaginosis: 1 capsule in the morning and in the evening for 7 days or 1 capsule daily for 14 days.In preparation for planned gynecological surgeries, prenatal preparation of pregnant women for planned gynecological surgeries, prenatal preparation of pregnant women at risk for bacterial vaginosis: 1 capsule in the morning and evening for 7 days or 1 capsule daily for 14 days - as part of complex therapy.The capsule should be introduced into the vagina, moistened it with a small amount of water to accelerate the dissolution of the drug.Dosing regimen should be adjusted depending on the severity of the clinical effect

Side effect

Allergic reactions: itching, burning, redness in the genital area.Other: strengthening mucous secretions from the vagina.

Contraindications

• vulvovaginal candidiasis (thrush), - childhood and adolescence up to 18 years, - hypersensitivity to the components of the drug
  

Application for pregnancy and breastfeeding

Perhaps the use of the drug Lactinol during pregnancy and lactation (breastfeeding).

Special instruction

After administration, the capsule dissolves, leaving no stains on the underwear or smell.The use of the drug can be combined with the simultaneous appointment of antibacterial, antiviral and immunomodulatory drugs.It is not recommended to use the drug with spermicidal agents.The drug is intended for use in women over 18 years.

Overdose

Cases of overdose have not been reported to date.

Drug interaction

Possible simultaneous use of antibacterial and antiviral drugs.Clinically significant cases of interaction have not been registered.

Storage terms and conditions

The drug should be stored out of reach of children at a temperature not higher than 25°C. shelf life - 3 years.