Expiration date: 05/2025
The composition and form of issue:
Capsules 1 caps.
active substance:
nifuroxazide 100, 200 mg
excipients: sucrose corn starch powdered cellulose magnesium stearate
capsule shell 100 mg: titanium dioxide S. I. 77891 (E171) quinoline yellow S. I. 47005 (E104) orange yellow S. I. 15985 (E110) azorubin S. I. 14720 (E122) kosinil red S. I. 16255 (E124) gelatin
capsule shell 200 mg: titanium dioxide S. I. 77891 (E171) quinoline yellow S. I. 47005 (E104) azorubin S. I. 14720 (E122) kosinil red S. I. 16255 (E124) gelatin
Suspension 5 ml
active substance:
nifuroxazide 200 mg
excipients: sucrose sodium hydroxide methylparahydroxybenzoate ethanol 96% carbomer citric acid banana flavor distilled water
Capsules 100 mg: in blisters PVC film / aluminum foil 10 PCs. in a pack of cardboard 3 blisters.
Capsules 200 mg: in blisters PVC film / aluminum foil 8 PCs. in a pack of cardboard 2 or 4 blisters.
Suspension: in bottles of dark glass with a capacity of 100 ml, with aluminum lids with the control of the first opening, 90 ml in a pack of cardboard with a measuring spoon 1 bottle.
Description of dosage form:
Capsules 100 mg: gelatin, solid, No. 2, opaque, yellow content-yellow powder.
Capsules 200 mg: gelatin, solid, transparent, yellow content-powder or powder with inclusions in the form of small pieces of compressed mass, or compressed powder, which crumbles when lightly pressed, yellow.
Suspension: thick, banana-scented, yellow.
Pharmacokinetics:
After oral administration nifuroxazide is practically not absorbed from the digestive tract, and its antibacterial effect is exerted exclusively in the lumen of the intestine. Completely excreted in the feces. The rate of elimination depends on both the dose of the drug and the motility of the intestinal tract.
Description of pharmacological action:
Broad-spectrum antimicrobial agent for the treatment of gastrointestinal infections. Nifuroxazide is a derivative of 5-nitrofuran.
It is assumed that the antimicrobial and antiparasitic activity of nifuroxazide is caused by the presence of NO2-group in its composition, which acts on the bacterium and causes a pronounced effect in intestinal infectious diseases.
Active against: gram-positive microorganisms-Streptococcus pyogenes, Staphylococcus pyogenes, Clostridium gram-positive enterobacteria-E. coli, Salmonellae, Shigellae, Klebsiella, Enterobacter, Vibrio cholerae, Campilobacter, Edwarsieila, Citrobacter, Yersinia.
Nifuroxazide no effect on the saprophytic flora that does not disrupt the balance of normal intestinal flora.
Indications:
Acute and chronic diarrhea of infectious Genesis (but without signs of worm infestation).
Contraindications:
- hypersensitivity to nitrofuran derivatives
- newborn period (up to 1 month), prematurity.
Use during pregnancy and lactation:
It can be prescribed to pregnant and lactating women.
Side effect:
Allergic reaction.
Drug interaction:
There is no evidence that nifuroxazide interacts with other drugs.
Dosage and administration:
Inside.
Adults and children older than 7 years, the drug is prescribed 200 mg 4 times a day, the daily dose is 800 mg.
Children 2-7 years the drug is prescribed 200 mg 3 times a day, the daily dose is 600 mg.
Children under the age of 2 years, the drug is prescribed only in the form of a suspension. For dosing, a measuring spoon with a volume of 5 ml is used, having a graduation of 2, 5 ml.
Before use, the suspension must be well mixed.
Children aged 1-6 months appoint 100 mg (2, 5 ml or 1/2 scoop) 2-3 times a day children from 7 months to 2 years-100 mg 4 times a day children from 2 to 7 years-200 mg (5 ml) 3 times a day.
Therapy with nifuroxazid should not exceed 7 days.
Overdose:
There are no specific symptoms of overdose.
Standard emergency measures are recommended.
Precautionary measures:
In the treatment of diarrhea, simultaneously with nifuroxazide therapy, rehydration therapy (oral or intravenous) should be carried out in accordance with the patient's condition and the intensity of diarrhea.
It is forbidden to use alcohol during therapy with nifuroxazide.
