Expiration date: 09/2025

pharmachologic effect 

Clotrimazole is a broad spectrum antifungal agent for topical action.

Antifungal effect of active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of the cell membrane of fungi that alters the permeability of the membrane and causes a subsequent cell lysis.

In low concentrations fungistatic effect and in large - fungicide, not only in proliferating cells.

The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of the fungal cells.

Effective against:

• Dermatophytes.
  
• Yeast-like fungi and molds.
  
• Exciter multi-colored lichen Rityriasis versicolor (Malassezia furfur).
  
• Exciter erythrasma.
  

It has antimicrobial activity against:

• Staphylococci.
  
• Streptococci.
  
• Bacteroides.
  
• Gardnerella vaginalis.
  

testimony

• Fungal diseases of the skin, including skin folds and feet, caused by dermatophytes, molds and yeast.
  
• Pityriasis versicolor.
  
• Erythrasma.
  
• Fungal infections, complicated by secondary pyoderma.
  

Contraindications

• Hypersensitivity to clotrimazole or excipients.
  
• I trimester of pregnancy.
  
• Children under 2 years old.
  

Carefully:

• Lactation.
  

Pregnancy and breast-feeding

In clinical and experimental studies, it was found that the use of the drug during pregnancy or during breast-feeding has a negative impact on the health of the woman or the fetus (child).

However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.

Application of the drug directly to the lactating mammary gland is contraindicated.

special instructions

Avoid contact with the drug on the wound surface.

Patients with hepatic insufficiency should periodically monitor liver function.

When you see signs of hypersensitivity or irritation of the treatment is stopped.

If there is no improvement within 4 weeks after starting treatment should consult with your doctor to repeat microbiological testing to check the sensitivity of microorganisms to clotrimazole.

Composition

100 g of gel contains: clotrimazole 1 g

Excipients: Castor oil redkosshity polyacrylate, sodium hydroxide, polysorbate-80 (Tween-80), purified water

Dosing and Administration

Outwardly.

The gel is applied with a thin layer 2-3 times a day on previously cleaned (with soap with a neutral pH) and dry the affected skin and rub gently.

After application of the gel should not bandage.

The recommended single dose: on the skin area 10 cm 2 is applied from the tube gel strip 5-7 mm in length.

The course of treatment is selected individually depending on the severity of the disease, the localization and the effectiveness of therapy.

tinea treatment is carried out at least 4 weeks tinea versicolor - 1-3 weeks, erythrasma - 2-4 weeks.

Fungal diseases of the skin stop treatment is recommended to continue for a further 2 weeks at least after elimination of the symptoms of the disease.

Side effects

• Itching.
  
• Burning.
  
• Tingling in the field of application of the gel.
  
• The appearance of erythema, blisters, swelling, irritation and flaking of the skin.
  
• Allergic reactions:
  
• Itching.
  
• Urticaria.
  

Drug interactions

Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole, while the application.

Overdose

Overdose is unlikely, even when applying the drug on extensive areas of the skin due to its low absorption.

In case of accidental ingestion, the following symptoms: anorexia, nausea, vomiting, abdominal pain, abnormal liver function. Rare: drowsiness, hallucinations, frequent urination, allergic reactions.

Treatment: symptomatic therapy.