Expiration date: 09/2025

Testimony 

Infectious-inflammatory diseases of mild and moderate severity, caused by sensitive microorganisms:

• infections of the lower respiratory tract (pneumonia, exacerbation of chronic bronchitis);
  
• acute bacterial sinusitis;
  
• infection of the urinary tract and the kidney (including acute pyelonephritis);
  
• infections of skin and soft tissues (festering atheroma, abscess, boils);
  
• chronic bacterial prostatitis;
  
• intraabdominal infections (in combination with antibacterial drugs acting on the anaerobic microflora);
  
• tuberculosis (in the complex therapy of drug-resistant forms).
  

Active substance: levofloxacin (levofloxacin)

Tablets, film-coated. 1 tablet contains:

levofloxacin (hemihydrate) 500 mg

Clinico-pharmacological group: Antibacterial drug group of fluoroquinolones

Pharmaco-therapeutic group: Antimicrobial agent, fluoroquinolone

Side effects

From the nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, movement disorders, seizures.

From the sensory organs: visual impairment, hearing, olfactory, gustatory and tactile sensitivity.

From the side of cardiovascular system: decrease in blood pressure, vascular collapse, tachycardia, prolonged QT interval, atrial fibrillation.

From the digestive system: nausea, vomiting, diarrhea (including blood), indigestion, loss of appetite, abdominal pain, pseudomembranous colitis; elevated liver transaminases, hyperbilirubinemia, hepatitis, goiter.

From the metabolic: hypoglycemia (increased appetite, increased sweating, tremor, nervousness).

From the side of musculoskeletal system: arthralgia, muscular weakness, myalgia, rhabdomyolysis, tendon rupture, tendonitis.

From the urinary system: gipercreatininemia, interstitial nephritis, acute renal failure.

The bodies of the blood: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage.

Allergic reactions: itching and hyperemia of the skin, swelling of the skin and mucous membranes, hives, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospasm, dyspnea, anaphylactic shock, allergic pneumonitis, vasculitis.

Other: photosensitivity, asthenia, exacerbation of porphyria, persistent fever, development of superinfection.

Contraindications

• epilepsy;
  
• the defeat tendons associated with taking quinolones in history;
  
• child and adolescence to 18 years;
  
• pregnancy;
  
• lactation;
  
• hypersensitivity to levofloxacin, other fluoroquinolones or other components of the drug in history.
  

With caution: advanced age (high likelihood of having a concomitant loss of kidney function), the deficit glukozo-6-fosfatdegidrogenaza.

Application of pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

Application for violations of liver function

When violation of the liver dose adjustment is not required because the amount of metabolism of levofloxacin in the liver is limited.