Expiration date: 04/2025
Structure and Composition:
Solution for infusion 1.2%
1 vial contains thioctic acid 600 mg
Excipients: meglumine, Macrogol 300 Water for Injection
in dark glass bottles of 50 ml in the paper cartons 1 or 10 bottles (with outboard protective case).
Film-coated tablets
1 tablet contains thioctic acid 600 mg
Excipients: lactose, talc MCC colloidal silica lactose monohydrate, sodium carboxymethylcellulose simethicone methylhydroxypropylcellulose (hypromellose) Magnesium stearate macrogol 6000, sodium lauryl sulfate
in blister 10 pcs. in the box 3, 6 or 10 blisters.
Description pharmaceutical form:
Solution (1.2%), yellowish green or pale yellow.
Tablets are light yellow in color with white patches, kapsulovidnoy form, film-coated, with the risk on both sides.
Pharmacokinetics:
Once inside quickly and almost completely absorbed from the gastrointestinal tract. Excreted by the kidneys, mainly as metabolites formed by oxidation and side chain conjugation. T1 / 2 - 20-50 minutes.
Description of the pharmacological actions:
It acts as a coenzyme in the oxidative decarboxylation of alpha-keto acids. It helps to reduce blood glucose and increased glycogen content in the liver. On pharmacologically similar to thioctic acid vitamins of group B.
Testimony:
Diabetic polyneuropathy.
Contraindications:
Hypersensitivity.
Side effect:
From the nervous system and sensory organs: rarely - seizures, double vision (after / in the introduction) the rapid introduction - increased intracranial pressure.
Cardio-vascular system and blood (blood, hemostasis): purpura (purpura), thrombophlebitis (after / in the introduction).
Allergic reaction at the injection site urticaria, systemic reactions up to anaphylactic shock.
Other: hypoglycemia, indigestion (ingestion), after a quick introduction may be a feeling of heaviness in the head, difficulty breathing (tested myself).
Drug Interactions:
It enhances the action of insulin and oral hypoglycemic agents, reduces the effect of cisplatin (rr d / in.), With a sugar molecule forms a poorly soluble complex compounds.
Rr d / inf. incompatible with the glucose solution, Ringer's solution and that can react with SH-groups or disulfide bonds.
Dosage and administration:
B / in slowly (20-30 min), as an infusion (concentrate for solution for infusion pre-diluted in 50-250 ml saline 0.9%), 600 mg / day (1 ampoule of 20 ml of a 3% concentrate or 1 vial of 50 ml of 1.2% solution). In applying the infusion vials are manufactured directly from them, while using the accompanying pendant dimming cases. The course of 2-4 weeks. After a course in / infusion inside, not liquid, a small amount of liquid at 300-600 mg (Table 0.5-1.) 1 times a day for 3 months.
Overdose:
Symptoms include nausea, vomiting, headache.
Treatment: symptomatic.
Precautionary measures:
While the use of insulin and oral hypoglycemic agents requires constant monitoring of blood glucose levels, especially in the initial stages of treatment. In some cases, in order to avoid hypoglycemia requires a reduction in the dose of insulin or oral hypoglycemic agents.
Special instructions:
Alcohol weakens the therapeutic effect of thioctic acid.
