Expiration date: 03/2025

Dosage form

Eye drops

Composition

1 ml contains

active substance: latanoprost 50 mcg

timolol(maleate) 5 mg,

excipients: disodium phosphate dodecahydrate,sodium dihydrogen phosphate dihydrate, 1M sodium hydroxide solution/chlorotoluidines, sodium chloride, benzalchloride, purified water.

Description 

Clear, colourless solution without visible particles

Pharmacotherapeutic group

Protivoglaucomny drugs and miotti. Beta-blockers.

Pharmacological properties

Pharmacokinetics

The maximum concentration latanoprosta (about 15-30ng/ml) in watery moisture is achieved through 2 h after topical application. Polarimery eye drops latanoprost is distributed primarily in prednisolone, in the conjunctiva and in the ages and only minor Kolichestvennaya reaches the posterior segment. Metabolism latanoprost practically happens in the tissues of the eye. The main metabolism occurs in the liver. Preodolevaetsya of plasma is 17 minutes The main metabolites,1,2-dinor and 1,2,3,4-tetranor-metabolites have little or labourites activity and mainly excreted in the urine.

The local application timolola maleate quickly protetores cornea. After instillation of eye drops maximum concentration timolol watery moisture of the eye is achieved through 1 h. the half-life in plasmodesmatal about 6 h. a small amount of timolol maleate enters systemdiskroot by absorption through the blood vessels of the conjunctiva, nasal mucosa and kutnohorite. Excretion of the metabolites of timolol are carried out primarily by the kidneys.

Pharmacodynamics

Combined protivoglaucomny the drug lowers intraocular pressure by reducing the secretion of aqueous humor.

Latanoprost is an analogue of prostaglandin F2a selektivnye agonist of the FP receptor. Latanoprost reduces intraocular pressure potamogalidae outflow of aqueous humor and provides protivoglaucomnoe action. Onewellness action latanoprost associated with increased uveoscleral outflow. Being cared significant effect on products watery moisture and is not affected nematologicheskiy barrier.

Timolol is a nonselective blocker of beta-adrenergic receptors neznachitelno internal AGR. The local application reduces vnutrigospitalina by reducing the formation of aqueous humor and its outflow debolshevisation.

Indications for use

- elevated intraocular pressure in patients otkratougolnaya glaucoma and ocular hypertension

Method of application and doses

1 drop conjunctival eye bag once a day. Stockades should not exceed 1 drop per day.

In the case of a joint application with another Duprost oftalmologicheskiy time interval of at least 5 minutes between application. Should snimatelj contact lenses before instillation of the drug and wear them again only after 15 minutes.

Contraindications

• hypersensitivity to latanoprost, timolol elitehome component of the drug
  
• bronchial asthma or other chronic lung obstructability
  
• sinusova aetiology, AV blockade II and III, serdechnososudistye, cardiogenic shock
  
• children's age (the efficacy and safety of unmounted)
  

Side effects

Very often (?1/10):

-increased pigmentation of the iris

Often (?1/100, <,,1 10="" :="" p="">,

-eye irritation (including stinging, burning and itching),eye pain

Not often (?1/1000, <,,1 100="" :="" p="">,

-redness of eyes, conjunctivitis, blurred vision, povyshennaya, blepharitis, corneal damage

- headache

- skin rash, itching

Side effects when using latanoprost:

- dizziness

- changes hair eyelashes (increased length, thickness, pigmentation number). Point epithelial erosions, periorbital edema, vospaleniya shell / uveitis, macular oedema (afakica, pseudoperichaeta with damage to the posterior capsule of the lens or in patients with investigatory risk of developing macular edema). Dry eye, keratitis, technogenity and erosions, wrong eyelashes sometimes resulting in eye irritation

- palpitations, aggravation of angina in patients with usesometime diseases

- asthma, exacerbation of asthma, dyspnea

- darkening of the skin around the eyes

- joint pain, muscle pain

- chest pain

Side effects when using timolol:

- signs and symptoms of systemic allergic reactions, including angioedema, urticaria, localized and generalized rash

depression, memory loss, decreased libido, insomnia,nightmares

- dizziness, paresthesia, cerebral ischemia, Narchemashvili circulation, increase in signs and symptom of myasthenia gravis, syncope

- signs and symptoms of irritation, including ocular keratitis,reduced corneal sensitivity and dry eyes, visual disturbances, vkluchaetsia of refraction (due to a withdrawal of meiotic treatment), diplopia, ptosis,choroidal (after filtering surgery)

- ringing in the ears

- trepetanie, arrhythmia, bradycardia, cardiac arrest,heart block, congestive heart failure

- hypotension, Raynaud's phenomenon, cold hands and feet

- bronchospasm (predominantly in patients with already sushestvovaniya), shortness of breath, cough

- nausea, diarrhea, dyspepsia, dry mouth

- hair loss, psoriaza rash or exacerbation of psoriasis

- asthenia, fatigue, chest pain, edema

Drug interactions

With simultaneous use with blockers of collegenow, drugs that reduce the activity of catecholamines,beta-blockers, antiarrhythmic drugs (including amiodarone echinilin), cardiac glycosides of the digitalis group, cholinomimetics,narcotic analgesics and monoamine oxidase inhibitors may seleniumcontaining actions and/or the development of severe bradycardia.

While the use of timolol maleate with adrenalinoman developed mydriasis.

While the use of the drug sbeta-blockers may increase blood sugar, what to vietnameselove symptoms of hyperglycemia.

Special instructions

Cardiac failure should be adequately, reguliruetsya beginning therapy with timolol. Patients with severe heart disease anamnese should be under the careful supervision of a physician. After the introduction of tamamlanamad possible respiratory reactions and cardiac reactions, including Smarties of bronchospasm in patients with asthma and rarely death in Association serdechnoi failure. Beta-blockers should be used with caution in patientso spontaneous Hypo-glycemia or because beta blockers can mask hypoglycemia symptomology. Beta-blockers can mask the signs of hyperthyroidism and cause to worsening of angina, severe diseases of the peripheral and Central circulation and hypotension.

The use of two local beta-blockers or two masterprofile is not recommended.

The drug can cause gradual change in eye color due to increase the amount of brown pigment in the iris. When applying latanoprostum increase in the iris pigmentation, the effect is mostly patsientov with mixed colors of iridescent shells. Usually caricabatteria around the pupil spreads concentrically towards the periphery postradavshikh eyes, but the entire iris or parts of it may become more brown.A further increase in brown iris pigment is not observed pokarekare treatment, but the changed color can be lengthy.

Before starting treatment patients should be poinformowanie changes eye color. Unilateral treatment can result in heterochromia postoyannoi.

While treatment with latanoprost can nabludatyelnii edema, including macular edema custody. Macular otherassets mainly in arakich patients, aphakic patients with paragenesia lens capsule. Duprost should be used with caution in adapalene.

Duprost contains benzalkonium chloride, which obyknovennoye as a preservative in ophthalmic preparations. Benzalchloride is known to cause keratopathy dotted and / imitaciones ulcerative keratopathy, may cause eye irritation and is known to discolour soft contact lenses. Therefore contact lenses to situational, and then they can be inserted again after 15 minutes after instillation.

If one dose is missed treatment should continue in alicemike, with the following dose (i.e., dose double). It is recommended that ostorozhnosti the case of patients with neovascular and congenital glaucoma, because otsutstvujet data on the safety of use.

Pregnancy and lactation

The drug Duprost not recommended for berekeningen, except in cases of obvious need (with clear evidence and analysis of sootnosheniya/risk to mother and fetus).

The drug is excreted in milk, therefore, if primegenerator mothers should stop breast-feeding.

Features of the influence of the drug on to sposobnostyami a vehicle or potentially dangerous machinery

Given the side effects of the drug unfollow to drive vehicles and other potentially dangerous machinery

Overdose

Symptoms: eye irritation, conjunctival hyperemia yleiskielen, dizziness, headache, arrhythmia, bradycardia,bronchospasm, nausea, vomiting, fatigue, hot flashes and sweating.

Treatment: symptomatic therapy.

Shape of release and packing

2.5 ml solution in a transparent plastic bottle with copernicusstraat 5 ml closed with a polymer cap with safety ring. Poolname vial-dropper with instructions on gosudarstvennoi Russian languages in a cardboard box.

Storage conditions

Protected from light place at temperature from 2 °C to 8 °C.

After opening the bottle the drug should be stored pretemperature not above 25 °C and use within 4 weeks

Keep out of reach of children!

Shelf life

3 years.

Do not use after expiration date