Expiration date: 05/2025
pharmachologic effect
Selective blocker of postsynaptic alpha1-adrenergic receptors. By blocking these receptors resistance (arterial) blood vessels, causing their expansion, reduction in systemic vascular resistance and lowering blood pressure. Decreases afterload on the heart. It was also a decrease in the tone of the capacitance (venous) blood vessels, reduces preload on the heart. Unlike selective blockers, alpha 1 and alpha2 adrenergic receptors causes marked tachycardia.
Terazosin has a lipid-lowering effect: on the background of its application, a decrease of cholesterol, LDL and VLDL (the mechanism of occurrence of these effects is not clear). Furthermore, terazosin normalizes urination in patients with benign prostatic hypertrophy (BPH), prostate cancer, because it is blocking the postsynaptic alpha1-adrenoceptors triangle smooth muscle of the bladder neck and proximal urethra and prostate - reduces the resistance to current urine.
testimony
Arterial hypertension, chronic congestive heart failure (in combination therapy), prostate adenoma.
dosage
In order to avoid "a phenomenon of the first dose" is necessary to start treatment with a low dose - 1 mg, take it right before bedtime, after which the patient should be in bed for several hours. Increasing the dose gradually produce: doubling during the week. The maintenance dose depends on the evidence and the effectiveness of treatment is 2-10 mg (rarely - 20 mg) 1 times / day.
Side effect
Early treatment may cause "first dose phenomenon" - orthostatic hypotension up to fainting. In addition, the treatment of terazosin may experience dizziness, headache, asthenia, somnolence, palpitations, nausea, nasal congestion, blurred vision, peripheral edema, weight gain, rarely - postural hypotension, tachycardia, impotence, hemodilution effects.
Contraindications
Hypersensitivity to terazosin and other alpha-adrenoceptor blocking agents.
special instructions
In pregnancy, terazosin used with caution, after careful comparison of the possible risk to the fetus and positive effects for the mother.
The combined use of terazosin with other antihypertensive agents mutual strengthening hypotensive effect, which requires a corresponding adjustment of doses.
