Nicotinylcodeine cholinergic receptors (n-cholinergic receptors) are mainly localized on the postsynaptic membranes at synapses in the skeletal muscles, autonomic ganglia (ganglia), medulla of the adrenal gland and sinocarotid zones (both evolutionary recent education — ganglia), some interneuronal contacts of the CNS.

n-Anticholinergics have the ability to shield the receptors and prevent their stimulation by acetylcholine. Thereby can block the transmission of impulses from the respective nerves to the striated muscle, adrenal gland, carotid sinuses, from neuron to neuron with preganglionic to postganglionic autonomic fibers.

Under the action of the ganglionic autonomic ganglia become insensitive not only to endogenous acetylcholine, but also to various exogenous stimuli cholinergic (nicotine, lobeline, cytisine, etc.). Blocked the sympathetic and parasympathetic components, however, for different drugs in different sequences and with different power.

Interrupting the nerve impulses in the ganglia, the ganglionic alter the function of organs supplied with autonomic innervation. At the same lowered blood pressure, decreases the flow of vasoconstrictor impulses to blood vessels and expands peripheral vessels, primarily arterioles, decreases secretion and peristalsis of the gastrointestinal tract. Initially, ganglionic (gexametoni benzolsulfonat, azametonia bromide, etc.) are relatively widely used for the treatment of hypertension, ulcers stomach and duodenal ulcers, other diseases. However, due to the caused by these drugs side effects and the creation of new, more effective drugs, ganglionic currently have limited application. Sometimes they are used for relief of hypertensive crises and in complex therapy of peptic ulcer disease.